Faculty of Engineering, Department of Metallurgical and Materials Engineering, Karadeniz Technical University, Trabzon, Turkey.
The V. Y. Akhundov Scientific Research Medical Preventive Institute, Baku, Azerbaijan; Faculty of Chemistry-Metallurgy, Bioengineering Department, Yildiz Technical University, Istanbul, Turkey.
Int J Pharm. 2024 Dec 5;666:124746. doi: 10.1016/j.ijpharm.2024.124746. Epub 2024 Sep 23.
Malaria, caused by Plasmodium parasites transmitted through Anopheles mosquitoes, remains a global health burden, particularly in tropical regions. The most lethal species, Plasmodium falciparum and Plasmodium vivax, pose significant threats to human health. Despite various treatment strategies, malaria continues to claim lives, with Africa being disproportionately affected. This review explores the advancements in drug delivery systems for malaria treatment, focusing on polymeric and lipid-based nanoparticles. Traditional antimalarial drugs, while effective, face challenges such as toxicity and poor bio-distribution. To overcome these issues, nanocarrier systems have been developed, aiming to enhance drug efficacy, control release, and minimize side effects. Polymeric nanocapsules, dendrimers, micelles, liposomes, lipid nanoparticles, niosomes, and exosomes loaded with antimalarial drugs are examined, providing a comprehensive overview of recent developments in nanotechnology for malaria treatment. The current state of antimalarial treatment, including combination therapies and prophylactic drugs, is discussed, with a focus on the World Health Organization's recommendations. The importance of nanocarriers in malaria management is underscored, highlighting their role in targeted drug delivery, controlled release, and improved pharmacological properties. This review bridges the gap in the literature, consolidating the latest advancements in nanocarrier systems for malaria treatment and offering insights into potential future developments in the field.
疟疾是由疟原虫通过按蚊传播引起的，仍然是全球健康负担，特别是在热带地区。最致命的疟原虫种类，恶性疟原虫和间日疟原虫，对人类健康构成重大威胁。尽管有各种治疗策略，疟疾仍在夺走生命，非洲受影响尤为严重。本综述探讨了疟疾治疗中药物传递系统的进展，重点关注聚合物和基于脂质的纳米粒子。传统的抗疟药物虽然有效，但面临毒性和生物分布不良等挑战。为了克服这些问题，已经开发了纳米载体系统，旨在提高药物疗效、控制释放和最小化副作用。本文研究了载有抗疟药物的聚合物纳米胶囊、树枝状大分子、胶束、脂质体、纳米脂质体、非诺司体和外泌体，全面概述了疟疾治疗纳米技术的最新进展。讨论了抗疟治疗的现状，包括联合疗法和预防性药物，并重点介绍了世界卫生组织的建议。强调了纳米载体在疟疾管理中的重要性，突出了它们在靶向药物传递、控制释放和改善药理性质方面的作用。本综述填补了文献中的空白，整合了疟疾治疗中纳米载体系统的最新进展，并为该领域的潜在未来发展提供了见解。
