Puttappa Nethravathi, Kumar Raman Suresh, Kuppusamy Gowthamarajan, Radhakrishnan Arun
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research (Deemed to be University), Ooty, Tamil Nadu, India.
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research (Deemed to be University), Ooty, Tamil Nadu, India.
Acta Trop. 2019 Jul;195:103-114. doi: 10.1016/j.actatropica.2019.04.020. Epub 2019 Apr 27.
Malaria, one of the major infectious disease-causing sizeable morbidity, mortality and economic loss worldwide. The main drawback for the failure to eradicate malaria is the spread of multiple drug resistance to the majority of currently available chemotherapy. At present nanotechnology offers an advanced opportunity in the delivery of drugs and vaccines to the desired targeted site in the body following oral and systemic administration. It confers the major advantages like improving drug pharmacokinetic profiles, reduce dose frequency and reduction in drug toxicity. Hence, Nano-based drug delivery system can provide a promising prospect in the way of malaria treatment. This paper is a review of recent researches highlighting includes nanocarriers loaded antimalarial drugs for better therapeutic efficacy and future perspective in the treatment of malaria.
疟疾是全球导致大量发病、死亡和经济损失的主要传染病之一。未能根除疟疾的主要障碍是对大多数现有化疗药物产生多重耐药性的传播。目前，纳米技术为口服和全身给药后将药物和疫苗递送至体内所需靶点提供了一个先进的契机。它具有诸多主要优势，如改善药物的药代动力学特征、减少给药频率以及降低药物毒性。因此，基于纳米的药物递送系统在疟疾治疗方面可提供一个有前景的前景。本文综述了近期的研究，重点介绍了负载抗疟药物的纳米载体，以提高治疗效果以及疟疾治疗的未来展望。
