Department of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.; Department of Emergency, the Second Naval Hospital of Southern Theater Command of PLA, Sanya, China; Heatstroke Treatment and Research Center of PLA, Sanya, China.
Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.
Sci Total Environ. 2024 Dec 1;954:176476. doi: 10.1016/j.scitotenv.2024.176476. Epub 2024 Sep 24.
As global warming intensifies, heat waves occur more frequently around the world. Heat stress from hot and humid environments poses a significant threat to human health. It can cause a significant increase in core body temperature (CBT), and even lead to life-threatening heat stroke. Extremely high CBT is considered the most important clinical symptom and prognostic indicator of heat stroke. To study it, we implanted temperature-monitoring capsules into the abdominal cavities of rats to measure their CBT values. The rats were then exposed to different hot and humid environments to monitor the resultant changes in their CBTs. The results showed that heat stress could induce a three-phase thermoregulatory response in rats under different conditions. A temperature plateau was observed as part of the three-phase thermoregulatory response, at a similar CBT across different conditions. The duration of this plateau can reflect the thermotolerance of rats in hot and humid environments. The third stage of the three-phase thermoregulatory response reflects the pathogenesis of heat stroke, which may present the key stage of heat injury. Moreover, a certain range of humidity did not affect the thermoregulatory responses of rats, but exerted a significant impact once a certain threshold was reached. In this study, the CBTs of the rats in different environments were monitored to characterize their thermoregulatory responses under heat stress. In particular, the discovery of the plateau phase and humidity threshold may help to better understand the effects of high temperature and humidity conditions on living organisms.
随着全球变暖的加剧，世界各地的热浪越来越频繁。热和湿环境中的热应激对人类健康构成了重大威胁。它会导致核心体温（CBT）显著升高，甚至导致危及生命的中暑。极高的 CBT 被认为是中暑最重要的临床症状和预后指标。为了研究它，我们将温度监测胶囊植入大鼠的腹腔内，以测量它们的 CBT 值。然后，将大鼠暴露在不同的热湿环境中，以监测它们的 CBT 变化。结果表明，热应激可以诱导大鼠在不同条件下产生三相体温调节反应。作为三相体温调节反应的一部分，观察到温度平台，不同条件下的 CBT 相似。该平台的持续时间可以反映大鼠在热湿环境中的耐热性。三相体温调节反应的第三阶段反映了中暑的发病机制，可能是热损伤的关键阶段。此外，一定范围的湿度不会影响大鼠的体温调节反应，但一旦达到一定阈值，就会产生显著影响。在这项研究中，监测了不同环境下大鼠的 CBT，以描述它们在热应激下的体温调节反应。特别是，平台阶段和湿度阈值的发现可能有助于更好地了解高温高湿条件对生物体的影响。
