Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Eur Respir Rev. 2024 Sep 25;33(173). doi: 10.1183/16000617.0096-2024. Print 2024 Jul.
Recent bronchiectasis studies from large-scale multinational, multicentre registries have demonstrated that the characteristics of the disease vary according to geographic region. However, most perspectives on bronchiectasis are dominated by data from Western countries. This review intends to provide an Asian perspective on the disease, focusing on the established registries in India, Korea and China. Asian patients with bronchiectasis are less likely to show female predominance and experience exacerbations, are more likely to be younger, have milder disease, and have fewer options for guideline-recommended treatment than those living in other global regions. Furthermore, Asian bronchiectasis patients demonstrate different comorbidities, microbiological profiles and unique endophenotypes, including post-tuberculosis and dry bronchiectasis. Notably, each Asian region reveals further geographic variations and inter-patient differences. Future studies are warranted to better characterise Asian patients with bronchiectasis.
最近来自大型跨国多中心注册研究的支气管扩张症研究表明，疾病的特征因地理位置而异。然而，大多数支气管扩张症的观点都以来自西方国家的数据为主导。本综述旨在提供亚洲视角的支气管扩张症，重点关注印度、韩国和中国的已建立的注册中心。亚洲支气管扩张症患者女性优势和病情恶化的可能性较低，更年轻，疾病较轻，与生活在其他全球地区的患者相比，可选择的指南推荐治疗方案较少。此外，亚洲支气管扩张症患者表现出不同的合并症、微生物特征和独特的内表型，包括肺结核后和干性支气管扩张症。值得注意的是，每个亚洲地区都显示出进一步的地理差异和患者间差异。需要进一步的研究来更好地描述亚洲支气管扩张症患者。
