Promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in rats.

The promoting effect of trisodium nitrilotriacetate monohydrate (Na3NTA X H2O) on two-stage urinary bladder carcinogenesis in F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at levels of 0.01 and 0.05% was investigated. Administration of 2.0% Na3NTA X H2O significantly increased both the incidence and the number per 10 cm of basement membrane of preneoplastic lesions and papillomas of the urinary bladder in rats pretreated with 0.05% BBN. This result shows that Na3NTA X H2O has weak promoting activity in urinary bladder carcinogenesis.