Department of Biobank, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Chengdu, China.
Tibet Autonomous Region Clinical Research Center for High-altitude Stress, Endocrinology and Metabolism Disease, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital.C.T.), Chengdu, China.
Diabetes Obes Metab. 2024 Dec;26(12):5580-5589. doi: 10.1111/dom.15919. Epub 2024 Sep 26.
To explore the effectiveness of the Metawell programme on cardiometabolic risk factors in China, which combines meal replacement biscuits, a wireless scale, and a mobile phone application.
In this two-arm, parallel-design randomized study, 220 participants were randomly assigned to an intervention (n = 110) and a control (n = 110) group. Participants in the intervention group were instructed to use meal replacement products and scales for weight loss and monitoring, whereas participants in the control group received printed materials containing a sample diet and face-to-face weight loss education at enrolment. The trial lasted 6 months, including a weight loss period in Months 1-3 and a weight maintenance period in Months 3-6. Generalized estimating equations were used to compare differences between the two groups.
The median (interquartile range) ages of the intervention and control groups were 32.00 (28.00, 39.00) years and 33.00 (28.25, 41.00) years, with body mass indices of 28.20 (26.30, 30.95) kg/m and 27.70 (26.02, 29.70) kg/m, respectively. Participants in the intervention group experienced significantly greater decreases in waist circumference, hip circumference, triglycerides, total cholesterol: high-density lipoprotein cholesterol ratio, fasting blood glucose, fasting insulin, and homeostatic model assessment of insulin resistance index compared to the control group (p < 0.01). Among participants who did not regain weight during the maintenance period after weight loss, the reductions in systolic and diastolic blood pressure were significantly greater in the intervention group than in the control group (p < 0.05).
The Metawell programme of caloric restriction and remote monitoring can be adapted to overweight and obese people in China to reduce their cardiometabolic risk factors. Furthermore, there was a better improvement in blood pressure in participants who maintained the effects of weight loss.
探索结合代餐饼干、无线体脂秤和手机应用的迈拓卫（Metawell）计划对中国人群中心血管代谢危险因素的影响。
这是一项两臂平行设计的随机研究，共纳入 220 名参与者，随机分为干预组（n=110）和对照组（n=110）。干预组参与者被指导使用代餐产品和体脂秤进行减重和监测，而对照组参与者在入组时接受包含样本饮食和面对面减重教育的纸质材料。试验持续 6 个月，包括 1-3 个月的减重期和 3-6 个月的体重维持期。采用广义估计方程比较两组间的差异。
干预组和对照组的中位（四分位间距）年龄分别为 32.00（28.00，39.00）岁和 33.00（28.25，41.00）岁，体质指数分别为 28.20（26.30，30.95）kg/m 和 27.70（26.02，29.70）kg/m。与对照组相比，干预组的腰围、臀围、三酰甘油、总胆固醇/高密度脂蛋白胆固醇比值、空腹血糖、空腹胰岛素和稳态模型评估的胰岛素抵抗指数均显著降低（p<0.01）。在减重维持期体重未反弹的参与者中，干预组的收缩压和舒张压降低更为显著（p<0.05）。
热量限制和远程监测的迈拓卫计划可适用于中国超重和肥胖人群，以降低其心血管代谢危险因素。此外，对于维持减重效果的参与者，血压改善更好。
