Department of Endocrinology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, China.
Tibet Autonomous Region Clinical Research Center for High-Altitude Stress Endocrinology and Metabolism Disease, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, China.
JMIR Mhealth Uhealth. 2024 Oct 28;12:e47104. doi: 10.2196/47104.
Obesity is a rapidly increasing health problem in China, causing massive economic and health losses annually. Many techniques have emerged to help people with obesity better adhere to intervention programs and achieve their weight loss goals, including food replacement and internet-delivered weight loss consultations. Most studies on weight loss interventions mainly focused on the change in body weight or BMI; however, body fat, especially visceral fat mass, is considered the main pathogenic factor in obesity. In China, more reliable evidence is required on this topic. Moreover, it is unclear whether an integrated weight loss program combining food replacement products, mobile app-based platforms, and daily body composition monitoring using a wireless scale is useful and practical in China.
In this 2-arm, parallel-designed, randomized study, we explored the effectiveness and safety of the Metawell (Weijian Technologies Inc) weight loss program in China, which combines prepackaged biscuits, a wireless scale, and a mobile app.
Participants in the intervention group were guided to use food replacement products and a scale for weight loss and monitoring, whereas participants in the control group received printed material with a sample diet and face-to-face education on weight loss at enrollment. The intervention lasted for 3 months, and follow-up visits were conducted at months 3 and 6 after enrollment. Dual-energy x-ray absorptiometry and quantitative computed tomography were used to assess body fat. A multilevel model for repeated measurements was used to compare differences between the 2 groups.
In total, 220 patients were randomly assigned to intervention (n=110) and control (n=110) groups. Participants in the intervention group had significantly greater decreases in BMI, total body fat, visceral adipose area, and subcutaneous adipose area (all P<.001) than those in the control group. However, the rate of change in lean mass was not significantly different between the 2 groups (P=.62). Further, 35 participants in the intervention group reported adverse events. Constipation was the most frequently reported adverse event (11/110), followed by dizziness (6/110), hypoglycemia (4/110), fatigue (3/110), and gastritis (3/35).
The Metawell program was effective for weight loss. After the intervention, participants in the intervention group lost more body weight and body fat while retaining muscle mass than those in the control group.
肥胖是中国日益严重的健康问题，每年造成巨大的经济和健康损失。许多技术已经出现，帮助肥胖者更好地坚持干预计划并实现减肥目标，包括食物替代和互联网提供的减肥咨询。大多数减肥干预措施的研究主要集中在体重或 BMI 的变化上；然而，体脂肪，尤其是内脏脂肪量，被认为是肥胖的主要致病因素。在中国，需要更多关于这个主题的可靠证据。此外，尚不清楚在中国，结合食物替代产品、基于移动应用程序的平台以及使用无线秤进行日常身体成分监测的综合减肥方案是否有用和实用。
在这项 2 臂、平行设计、随机研究中，我们探讨了 Metawell（卫建技术公司）减肥计划在中国的有效性和安全性，该计划结合了预包装饼干、无线秤和移动应用程序。
干预组的参与者被引导使用食物替代产品和秤进行减肥和监测，而对照组的参与者在入组时接受了带有样本饮食的印刷材料和面对面的减肥教育。干预持续 3 个月，在入组后 3 个月和 6 个月进行随访。双能 X 射线吸收法和定量计算机断层扫描用于评估体脂肪。使用重复测量的多级模型来比较两组之间的差异。
共有 220 名患者被随机分配到干预组（n=110）和对照组（n=110）。与对照组相比，干预组的 BMI、总体体脂肪、内脏脂肪面积和皮下脂肪面积均显著降低（均 P<.001）。然而，两组之间的去脂体重变化率没有显著差异（P=.62）。此外，干预组有 35 名参与者报告了不良事件。便秘是最常报告的不良事件（11/110），其次是头晕（6/110）、低血糖（4/110）、疲劳（3/110）和胃炎（3/35）。
Metawell 方案对减肥有效。干预后，干预组参与者比对照组参与者体重和体脂肪减少更多，同时保留肌肉量。
