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罗望子木葡聚糖寡糖半乳糖侧链对肠道微生物群的益生元影响。

The prebiotic impacts of galactose side-chain of tamarind xyloglucan oligosaccharides on gut microbiota.

作者信息

Zhou Yubo, Tang Shuo, Lv Ying, Zhang Daihui, Huang Xiaode, Chen Yanan, Lai Chenhuan, Yong Qiang

机构信息

Jiangsu Co-Innovation Center of Efficient Processing and Utilisation of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, PR China.

Nanjing Institute of Comprehensive Utilization of Wild Plants, Nanjing, 211111, PR China.

出版信息

Heliyon. 2024 Sep 12;10(18):e37864. doi: 10.1016/j.heliyon.2024.e37864. eCollection 2024 Sep 30.

DOI:10.1016/j.heliyon.2024.e37864
PMID:39323792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11422031/
Abstract

To explore the impacts of galactose side-chain on the prebiotic activity of xyloglucan oligosaccharides (XGOS), XGOS and de-galactosylated XGOS (DG-XGOS) were prepared from tamarind using an enzymatic method. The differences in structural features of XGOS and DG-XGOS were systematically analyzed. Their fermentation characteristics of human fecal microbiota were explored. These results indicated that both XGOS and DG-XGOS promoted short-chain fatty acids (SCFAs) production, decreased pH, and changed the microbiota composition of the fermentation broth. Comparatively, DG-XGOS was more effective than XGOS in producing SCFAs, inhibiting the phylum Proteobacteria prevalence, and promoting the phyla Bacteroidetes and Actinobacteria prevalence. In summary, the xyloglucan degradation products exert potential prebiotic activity. Removing the galactose side-chains further enhances oligosaccharide utilization by fecal microbiota, offering a valuable approach to improve the biological efficacy of oligosaccharides.

摘要

为探究半乳糖侧链对木葡聚糖寡糖（XGOS）益生元活性的影响，采用酶法从罗望子中制备了XGOS和去半乳糖基化木葡聚糖寡糖（DG-XGOS）。系统分析了XGOS和DG-XGOS的结构特征差异。探究了它们对人体粪便微生物群的发酵特性。这些结果表明，XGOS和DG-XGOS均能促进短链脂肪酸（SCFAs）的产生，降低pH值，并改变发酵液中的微生物群组成。相比之下，DG-XGOS在产生SCFAs、抑制变形菌门的流行以及促进拟杆菌门和放线菌门的流行方面比XGOS更有效。总之，木葡聚糖降解产物具有潜在的益生元活性。去除半乳糖侧链进一步提高了粪便微生物群对寡糖的利用率，为提高寡糖的生物学功效提供了一种有价值的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/0db30b4421a6/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/a600df56a3c8/ga1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/2c441ec72bf2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/e76b53618d7b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/682174283c8c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/f5e939f73742/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/891f3dc8a670/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/fdc36b831697/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/eac5c9a0506d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/0db30b4421a6/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/a600df56a3c8/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/afc9233e97bb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/2c441ec72bf2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/e76b53618d7b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/682174283c8c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/f5e939f73742/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/891f3dc8a670/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/fdc36b831697/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/eac5c9a0506d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/11422031/0db30b4421a6/gr9.jpg

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