Longino Elizabeth S, Desisto Nicole G, Ortiz Alexandra S, Chowdhury Naweed I, Patel Priyesh N, Stephan Scott J, Yang Shiayin F
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Facial Plast Surg Aesthet Med. 2025 May-Jun;27(3):217-222. doi: 10.1089/fpsam.2024.0119. Epub 2024 Sep 26.
Studies suggest that mood disorders may affect perception of facial synkinesis, though none have analyzed effects on perceived benefit from chemodenervation. To measure the effect of depression, appearance anxiety, and other variables on chemodenervation benefit among patients with post-paralytic facial synkinesis. Prospective cohort. Patients volunteered and completed: Synkinesis Assessment Questionnaire (SAQ), Facial Clinimetric Evaluation Scale (FaCE), Center for Epidemiological Studies Depression Scale (CES-D), and Fear of Negative Appearance Evaluation Scale (FNAES). Multivariate regression was used to analyze the effect of CES-D, FNAES, and demographics on pre- and post-chemodenervation SAQ and FaCE. In total, 100 patients participated, 90% were female. Mean age was 56.4 (SD 12.3) years. The most common paralysis etiology was idiopathic (47%). Average synkinesis duration was 7.6 (6.2) years and treatment duration 4.9 (4.8) years. Older age and prior treatment ( < 0.05) were associated with reduced SAQ improvement; worse CES-D approached significance ( = 0.09). Reported history of anxiety was associated with greater SAQ improvement ( = 0.05). Factors associated with reduced FaCE improvement included higher baseline CES-D and prior treatment ( < 0.05). Older age, worse depression scores, and prior treatments may be associated with reduced patient-graded improvement following chemodenervation. History of anxiety may be associated with greater improvement.
研究表明，情绪障碍可能会影响对面部联带运动的感知，不过尚无研究分析其对化学去神经支配所带来益处的感知的影响。旨在测量抑郁症、外貌焦虑及其他变量对麻痹后面部联带运动患者化学去神经支配益处的影响。前瞻性队列研究。患者自愿参与并完成：联带运动评估问卷（SAQ）、面部临床计量评估量表（FaCE）、流行病学研究中心抑郁量表（CES-D）以及负面外貌评价恐惧量表（FNAES）。采用多变量回归分析CES-D、FNAES及人口统计学因素对化学去神经支配前后SAQ和FaCE的影响。共有100名患者参与，其中90%为女性。平均年龄为56.4（标准差12.3）岁。最常见的麻痹病因是特发性（47%）。平均联带运动持续时间为7.6（6.2）年，治疗持续时间为4.9（4.8）年。年龄较大和既往接受过治疗（<0.05）与SAQ改善程度降低相关；CES-D得分较差接近显著水平（=0.09）。报告有焦虑病史与SAQ改善程度更大相关（=0.05）。与FaCE改善程度降低相关的因素包括基线CES-D较高和既往接受过治疗（<0.05）。年龄较大、抑郁得分较差和既往接受过治疗可能与化学去神经支配后患者分级改善程度降低相关。焦虑病史可能与改善程度更大相关。
