Public Health, School of Medicine and Dentistry, Griffith University, Gold Coast, QLD, Australia.
Department of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.
Public Health Nutr. 2024 Sep 26;27(1):e176. doi: 10.1017/S1368980024001794.
Numerous studies have examined the relationship between overweight/obesity and iron deficiency anaemia (IDA) across diverse population groups, but a definitive link has not been clearly determined. This systematic review examined the association between overweight/obesity and IDA in women of reproductive age (WRA).
The initial search was performed in the CINAHL, Embase, MEDLINE, SCOPUS and Web of Science databases. The studies included should report at least one Fe status with/without an inflammatory marker, using the BMI to define overweight/obesity. Only baseline data were extracted for longitudinal studies.
Global.
Pregnant or non-pregnant women aged 18-50 years.
In total, twenty-seven papers were included (twelve addressing pregnant women and fifteen addressing non-pregnant women). Overall, most of the studies reported no association between overweight/obesity and Hb concentration. However, a positive association was reported more frequently in pregnant women. The association between overweight/obesity and serum ferritin concentrations was mixed. Most of the studies on non-pregnant women reported a positive association. Only a few studies measured hepcidin and inflammatory markers, and the majority revealed an increased level among overweight/obese WRA. Among pregnant women, overweight/obesity was positively associated with anaemia and IDA but negatively associated with iron deficiency (ID). Meanwhile, overweight/obese non-pregnant women were positively associated with anaemia, ID and IDA.
Overweight/obesity was associated with a decreased prevalence of anaemia and IDA but an increased prevalence of ID, while its association with several Fe markers was inconclusive. Further studies integrating the assessment of various Fe markers, inflammatory markers and hepcidin are needed.
许多研究已经在不同人群中研究了超重/肥胖与缺铁性贫血（IDA）之间的关系，但尚未明确确定明确的联系。本系统评价研究了育龄妇女（WRA）中超重/肥胖与 IDA 之间的关系。
最初在 CINAHL、Embase、MEDLINE、SCOPUS 和 Web of Science 数据库中进行了搜索。纳入的研究应至少报告一项 Fe 状态，同时使用 BMI 定义超重/肥胖。仅对纵向研究提取基线数据。
全球。
年龄在 18-50 岁的孕妇或非孕妇。
共有 27 篇论文被纳入（12 篇涉及孕妇，15 篇涉及非孕妇）。总体而言，大多数研究报告超重/肥胖与 Hb 浓度之间没有关联。然而，在孕妇中更频繁地报告了正相关关系。超重/肥胖与血清铁蛋白浓度之间的关联是混合的。大多数关于非孕妇的研究报告了正相关关系。只有少数研究测量了铁调素和炎症标志物，大多数研究表明超重/肥胖的 WRA 水平升高。在孕妇中，超重/肥胖与贫血和 IDA 呈正相关，但与缺铁（ID）呈负相关。同时，超重/肥胖的非孕妇与贫血、ID 和 IDA 呈正相关。
超重/肥胖与贫血和 IDA 的患病率降低有关，但与 ID 的患病率增加有关，而其与几种 Fe 标志物的关系尚无定论。需要进一步研究整合各种 Fe 标志物、炎症标志物和铁调素的评估。
