Department of Respiratory and Critical Care Medicine, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Department of Critical Care Medicine, Beijing Mentougou District Hospital, Capital Medical University affiliated Tongren Hospital, Beijing, China.
Biomarkers. 2024 Nov;29(7):427-433. doi: 10.1080/1354750X.2024.2410238. Epub 2024 Oct 10.
This study investigates the impact of diquat toxicity levels on in-hospital mortality rates among patients with acute diquat poisoning. It aims to clarify the relationship between diquat toxicity scores and the likelihood of death during hospitalization.
A retrospective cohort study was conducted on 98 individuals with acute diquat poisoning. Data on post-ingestion time, initial diquat plasma concentration, and clinical outcomes were systematically collected for all participants. The toxicity-index of diquat was calculated based on post-ingestion time and initial diquat plasma concentration. Logistic regression analysis was utilized to assess the association between the toxicity-index of diquat and in-hospital mortality rates, adjusting for potential confounding variables such as age, comorbidities, and treatment interventions.
The study found that the overall prevalence of in-hospital mortality was 34.7%, with 58.2% in males. The multivariable-adjusted regression coefficient for in-hospital mortality associated with the toxicity-index was 1.09, with a 95% confidence interval (CI) of 1.01-1.17. Subsequent exploratory subgroup analysis indicated that there were no significant interactions (all values for interaction were >0.05).
The study found that higher diquat toxicity-index values correlate with increased in-hospital mortality in acute diquat poisoning cases, indicating that the toxicity-index could be a useful biomarker for assessing mortality risk.
本研究旨在探讨百草枯毒性水平对急性百草枯中毒患者住院死亡率的影响。目的在于阐明百草枯毒性评分与住院期间死亡可能性之间的关系。
对 98 例急性百草枯中毒患者进行回顾性队列研究。对所有参与者的摄入后时间、初始百草枯血浆浓度和临床结局数据进行系统收集。根据摄入后时间和初始百草枯血浆浓度计算百草枯毒性指数。采用 logistic 回归分析评估百草枯毒性指数与住院死亡率之间的关联，同时调整年龄、合并症和治疗干预等潜在混杂因素。
研究发现，住院死亡率总体患病率为 34.7%，男性为 58.2%。与百草枯毒性指数相关的住院死亡率的多变量调整回归系数为 1.09，95%置信区间（CI）为 1.01-1.17。随后的探索性亚组分析表明，无显著交互作用（所有交互作用值均>0.05）。
本研究发现，较高的百草枯毒性指数值与急性百草枯中毒患者住院死亡率增加相关，表明毒性指数可作为评估死亡风险的有用生物标志物。
