Hassan Moomen, Canatan Ahmed N, Çakır Gizem, Pastırmacıoğlu Ege, Yorgancı Söğüt, Cumaoğulları Özge, Akçay Nimet İlke, Oygar Düriye Deren
Faculty of Medicine, Marmara University, Istanbul, TUR.
Faculty of Medicine, Eastern Mediterranean University, Gazimağusa, CYP.
Cureus. 2024 Aug 27;16(8):e67893. doi: 10.7759/cureus.67893. eCollection 2024 Aug.
Introduction Health-related quality of life (HR-QoL) is recognized as an important predictor of mortality and morbidity in end-stage renal disease (ESRD) patients receiving hemodialysis (HD). The goal of this study was to obtain HR-QoL scores using the Kidney Disease and Quality of Life questionnaire (KDQOL-36) (RAND Corporation, Santa Monica, CA) and to assess the factors affecting HR-QoL in ESRD patients receiving HD. Methods A multicenter cross-sectional study was performed using the KDQOL-36 for the assessment of HR-QoL of ESRD patients receiving HD in Northern Cypriot state hospitals. Alongside KDQOL-36 scores for assessing HR-QoL, sociodemographic as well as relevant laboratory data were collected. Spearman Correlations and multiple linear regression analyses using the 'stepwise' method were carried out to identify predictors of HR-QoL. Nonparametric tests were used to determine significantly (p<0.05) associated variables. Ethical approvals were received from the Northern Cypriot Ministry of Health and Eastern Mediterranean University Research and Publication Ethics Boards. Results One hundred and thirty-eight participants were recruited in this study, corresponding to 85.1% of the total study population. Participants had a mean age of 66.49 ± 13.35. 65.2% of the participants were males. Participants had low scores on most dimensions of quality of life, namely, Burden of Disease, Physical Component Summary (PCS), and Mental Component Summary (MCS) subscales. Particularly, females, unemployed patients, and patients with more comorbidities had significantly lower scores (p=0.003, p<0.001, and p=0.005, respectively). Spearman correlation analyses revealed multiple significant moderate correlations between sociodemographic data, laboratory variables, and scores. Furthermore, multiple linear regression analysis identified gender (p=0.006), total number of comorbidities (p=0.005), age (p<0.001), and patient care (p=0.019) as significant predictors of KDQOL-36 scores. Conclusion This study has shown that the quality of life of hemodialysis patients was highly impaired. Gender, current employment status, and presence of comorbidities were all significant independent factors affecting HR-QoL mean scores. Lastly, further studies regarding the implementation of routine HR-QoL surveillance and targeted interventions are required to better understand their potential therapeutic benefits.
引言 健康相关生活质量（HR-QoL）被认为是接受血液透析（HD）的终末期肾病（ESRD）患者死亡率和发病率的重要预测指标。本研究的目的是使用肾病与生活质量问卷（KDQOL-36）（兰德公司，加利福尼亚州圣莫尼卡）获得HR-QoL评分，并评估影响接受HD的ESRD患者HR-QoL的因素。方法 采用KDQOL-36对北塞浦路斯国立医院接受HD的ESRD患者的HR-QoL进行多中心横断面研究。除了用于评估HR-QoL的KDQOL-36评分外，还收集了社会人口统计学以及相关实验室数据。进行Spearman相关性分析和采用“逐步”法的多元线性回归分析以确定HR-QoL的预测因素。使用非参数检验来确定显著（p<0.05）相关变量。获得了北塞浦路斯卫生部和东地中海大学研究与出版伦理委员会的伦理批准。结果 本研究招募了138名参与者,占总研究人群的85.1%。参与者的平均年龄为66.49±13.35岁。65.2%的参与者为男性。参与者在生活质量的大多数维度上得分较低，即疾病负担、身体成分总结（PCS）和心理成分总结（MCS）子量表。特别是，女性、失业患者和合并症较多的患者得分显著较低（分别为p=0.003、p<；0.001和p=0.005）。Spearman相关性分析揭示了社会人口统计学数据、实验室变量和评分之间存在多个显著的中度相关性。此外，多元线性回归分析确定性别（p=0.006）、合并症总数（p=0.005）、年龄（p<；0.001）和患者护理（p=0.019）是KDQOL-36评分的显著预测因素。结论 本研究表明血液透析患者的生活质量严重受损。性别、当前就业状况和合并症的存在都是影响HR-QoL平均评分的显著独立因素。最后，需要进一步研究常规HR-QoL监测的实施和有针对性的干预措施，以更好地了解其潜在的治疗益处。
