Solberg O, Andersen B M
NIPH Ann. 1985 Jun;8(1):3-12.
Plasma concentration studies were performed in mice given high intravenous (i.v.) bolus injections or subcutaneous (s.c.) depot doses of benzylpenicillin. There was a marked difference in plasma concentration within and between individuals both after benzylpenicillin (BP) given i.v. and after benzylpenicillin procaine (BPP) given s.c. BP given i.v. resulted in a plasma half-life of 15.2 minutes, while BPP given s.c. resulted in a plasma half-life of 2.7 hours. Infection with an endotoxin-liberating meningococcal strain in BP-treated animals increased the plasma levels of BP compared with uninfected controls.
对给予大剂量静脉推注或皮下储库剂量苄青霉素的小鼠进行了血浆浓度研究。静脉注射苄青霉素（BP）后和皮下注射普鲁卡因苄青霉素（BPP）后，个体内部和个体之间的血浆浓度存在显著差异。静脉注射BP导致血浆半衰期为15.2分钟，而皮下注射BPP导致血浆半衰期为2.7小时。与未感染的对照相比，BP治疗的动物感染释放内毒素的脑膜炎球菌菌株会增加BP的血浆水平。
