Yang Xi, Chai Chengpeng, Chen Yun-Hsuan, Sawan Mohamad
CenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou 310030, China.
Institute of Advanced Technology, Westlake Institute for Advanced Study, 18 Shilongshan Street, Xihu District, Hangzhou 310024, China.
Bioengineering (Basel). 2024 Sep 13;11(9):916. doi: 10.3390/bioengineering11090916.
The human brain is a complex organ controlling daily activity. Present technique models have mostly focused on multi-layer brain tissues, which lack understanding of the propagation characteristics of various single brain tissues. To better understand the influence of different optical source types on individual brain tissues, we constructed single-layer brain models and simulated optical propagation using the Monte Carlo method. Based on the optical simulation results, sixteen optical source types had different optical energy distributions, and the distribution in cerebrospinal fluid had obvious characteristics. Five brain tissues (scalp, skull, cerebrospinal fluid, gray matter, and blood vessel) had the same set of the first three optical source types with maximum depth, while white matter had a different set of the first three optical source types with maximum depth. Each brain tissue had different optical source types with the maximum and minimum full width at half maximum. The study on single-layer brain tissues under different optical source types lays the foundation for constructing complex brain models with multiple tissue layers. It provides a theoretical reference for optimizing the selection of optical source devices for brain imaging.
人类大脑是控制日常活动的复杂器官。目前的技术模型大多聚焦于多层脑组织，而缺乏对各种单一脑组织传播特性的了解。为了更好地理解不同光源类型对单个脑组织的影响，我们构建了单层脑模型，并使用蒙特卡洛方法模拟光传播。基于光学模拟结果，16种光源类型具有不同的光能分布，且在脑脊液中的分布具有明显特征。五种脑组织（头皮、颅骨、脑脊液、灰质和血管）在前三种具有最大深度的光源类型上是相同的，而白质在前三种具有最大深度的光源类型上则不同。每种脑组织在半高宽最大和最小时具有不同的光源类型。对不同光源类型下单层脑组织的研究为构建具有多层组织的复杂脑模型奠定了基础。它为优化脑成像光源设备的选择提供了理论参考。
