基于分层反投影法的经颅光声计算机断层扫描
Transcranial photoacoustic computed tomography based on a layered back-projection method.
作者信息
Na Shuai, Yuan Xiaoyun, Lin Li, Isla Julio, Garrett David, Wang Lihong V
机构信息
Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Caltech Optical Imaging Laboratory, Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
出版信息
Photoacoustics. 2020 Oct 16;20:100213. doi: 10.1016/j.pacs.2020.100213. eCollection 2020 Dec.
A major challenge of transcranial human brain photoacoustic computed tomography (PACT) is correcting for the acoustic aberration induced by the skull. Here, we present a modified universal back-projection (UBP) method, termed layered UBP (L-UBP), that can de-aberrate the transcranial PA signals by accommodating the skull heterogeneity into conventional UBP. In L-UBP, the acoustic medium is divided into multiple layers: the acoustic coupling fluid layer between the skull and detectors, the skull layer, and the brain tissue layer, which are assigned different acoustic properties. The transmission coefficients and wave conversion are considered at the fluid-skull and skull-tissue interfaces. Simulations of transcranial PACT using L-UBP were conducted to validate the method. experiments with a newly developed three-dimensional PACT system with 1-MHz center frequency demonstrated that L-UBP can substantially improve the image quality compared to conventional UBP.
经颅人脑光声计算机断层扫描（PACT）的一个主要挑战是校正由颅骨引起的声学像差。在此，我们提出一种改进的通用反投影（UBP）方法，称为分层UBP（L-UBP），它可以通过将颅骨异质性纳入传统UBP来消除经颅光声信号的像差。在L-UBP中，声学介质被分为多层：颅骨与探测器之间的声学耦合流体层、颅骨层和脑组织层，它们被赋予不同的声学特性。在流体-颅骨和颅骨-组织界面处考虑传输系数和波转换。使用L-UBP进行了经颅PACT的模拟以验证该方法。使用新开发的中心频率为1MHz的三维PACT系统进行的实验表明，与传统UBP相比，L-UBP可以显著提高图像质量。
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