Department of Obstetrics and Gynecology, Kuopio University Hospital, 70210 Kuopio, Finland.
Department of Obstetrics and Gynecology, Central Finland's Hospital Nova, 40620 Jyväskylä, Finland.
Curr Oncol. 2024 Sep 19;31(9):5630-5642. doi: 10.3390/curroncol31090417.
Extensive surgery on advanced-stage epithelial ovarian cancer is associated with increased postoperative morbidity, which may cause a delay in or omission of chemotherapy. We examined postoperative complications and their effects on adjuvant treatment in patients undergoing primary debulking surgery (PDS).
Stage IIIC-IV epithelial ovarian cancer patients who underwent PDS between January 2013 and December 2020 were included. Patients were divided into two groups according to the radicality of the operation, i.e., extensive or standard surgery, and their outcomes were compared.
In total, 172 patients were included; 119 underwent extensive surgery, and 53 had standard surgery. Clavien-Dindo grade 3-5 (CDC 3+) complications were detected in 41.2% of patients after extensive operations and in 17% after standard surgery ( = 0.002). The most common CDC 3+ complication was pleural effusion. Despite the difference in the complication rates, the delay in chemotherapy did not differ between the extensive and standard groups ( = 0.98).
Complications are common after PDS. Extensive surgery increases the complication rate, but most complications can be treated effectively; therefore, a delay in adjuvant treatment is rare.
晚期上皮性卵巢癌的广泛手术与术后高发病率相关，这可能导致化疗的延迟或遗漏。我们研究了行初次肿瘤细胞减灭术（PDS）患者的术后并发症及其对辅助治疗的影响。
纳入 2013 年 1 月至 2020 年 12 月期间行 PDS 的 IIIC-IV 期上皮性卵巢癌患者。根据手术的彻底性将患者分为广泛手术组和标准手术组，比较两组患者的结局。
共纳入 172 例患者；119 例行广泛手术，53 例行标准手术。广泛手术组术后 41.2%的患者发生 Clavien-Dindo 分级 3-5 级（CDC3+）并发症，标准手术组为 17%（ = 0.002）。最常见的 CDC3+并发症是胸腔积液。尽管并发症发生率存在差异，但广泛手术组和标准手术组的化疗延迟无差异（ = 0.98）。
PDS 后并发症常见。广泛手术会增加并发症发生率，但大多数并发症可以有效治疗，因此辅助治疗的延迟很少见。
