S. H. Ho Urology Centre, Faculty of Medicine, Department of Surgery, The Chinese University of Hong Kong, 4/F LCW Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong.
Department of Experimental and Clinical Biomedical Science, University of Florence, Florence, Italy.
World J Urol. 2024 Sep 27;42(1):547. doi: 10.1007/s00345-024-05218-4.
To investigate the impact of ageing on survival outcomes in Bacillus Calmette-Guérin (BCG) treated non-muscle invasive bladder cancer (NMIBC) patients and its synergy with adequate BCG treatment.
Patients with NMIBC who received BCG treatment from 2001 to 2020 were divided into group 1 (< = 70 years) and group 2 (> 70 years). Overall Survival (OS), Cancer-Specific Survival (CSS), Recurrence-Free Survival (RFS), and Progression-Free Survival (PFS) were analyzed using the Kaplan-Meier method. Multivariable Cox regression analysis was used to adjust potential confounding factors and to estimate Hazard Ratio (HR) and 95% Confidence Interval (CI). Subgroup analysis was performed according to adequate versus inadequate BCG treatment.
Overall, 2602 NMIBC patients were included: 1051 (40.4%) and 1551 (59.6%) in groups 1 and 2, respectively. At median follow-up of 11.0 years, group 1 (< = 70 years) was associated with better OS, CSS, and RFS, but not PFS as compared to group 2 (> 70 years). At subgroup analysis, patients in group 1 treated with adequate BCG showed better OS, CSS, RFS, and PFS as compared with inadequate BCG treatment in group 2, while patients in group 2 receiving adequate BCG treatment had 41% less progression than those treated with inadequate BCG from the same group.
Being younger (< = 70 years) was associated with better OS, CSS, and RFS, but not PFS. Older patients (> 70 years) who received adequate BCG treatment had similar PFS as those younger with adequate BCG treatment.
探讨年龄对卡介苗（BCG）治疗非肌层浸润性膀胱癌（NMIBC）患者生存结局的影响及其与充分 BCG 治疗的协同作用。
将 2001 年至 2020 年间接受 BCG 治疗的 NMIBC 患者分为 1 组（<70 岁）和 2 组（>70 岁）。采用 Kaplan-Meier 法分析总生存期（OS）、癌症特异性生存期（CSS）、无复发生存期（RFS）和无进展生存期（PFS）。多变量 Cox 回归分析用于调整潜在混杂因素，并估计风险比（HR）和 95%置信区间（CI）。根据充分与不充分 BCG 治疗进行亚组分析。
共纳入 2602 例 NMIBC 患者：1 组（<70 岁）1051 例，2 组（>70 岁）1551 例。中位随访 11.0 年后，1 组（<70 岁）的 OS、CSS 和 RFS 优于 2 组（>70 岁），但 PFS 无差异。亚组分析显示，1 组中接受充分 BCG 治疗的患者在 OS、CSS、RFS 和 PFS 方面均优于 2 组中接受不充分 BCG 治疗的患者，而 2 组中接受充分 BCG 治疗的患者进展率比同组接受不充分 BCG 治疗的患者低 41%。
年龄较轻（<70 岁）与 OS、CSS 和 RFS 相关，但与 PFS 无关。接受充分 BCG 治疗的老年患者（>70 岁）的 PFS 与年轻患者相似。
