Dibb W L
Undersea Biomed Res. 1985 Sep;12(3):307-13.
The in vitro activity of prophylactic ear drops (Otic Domeboro) which are widely used by saturation divers against external otitis has been assessed. Four strains of Pseudomonas aeruginosa, 1 reference strain and 3 clinical isolates from cases of external otitis were employed. Two of the clinical isolates were from saturation divers who were using Otic Domeboro. Otic Domeboro solution was bactericidal even when diluted 1:2 in serum or broth. There were no significant differences between strains. There was no measurable inoculum effect. Survival kinetic analysis showed 60% killing at 5 min and 99.9% killing at about 2 h. Otic Domeboro is an effective anti-P. aeruginosa agent. There was no evidence of increased resistance among strains isolated from divers. The rate of killing in relation to usual prophylactic recommendations suggests that frequent dripping may be more effective. The therapeutic use of Otic Domeboro in saturation diving should be evaluated to avoid unnecessary use of antibiotic drops.
对饱和潜水员广泛使用的预防性耳滴剂（奥蒂多硼酸溶液）针对外耳炎的体外活性进行了评估。使用了4株铜绿假单胞菌，1株参考菌株和3株来自外耳炎病例的临床分离株。其中2株临床分离株来自使用奥蒂多硼酸溶液的饱和潜水员。奥蒂多硼酸溶液即使在血清或肉汤中稀释1:2时仍具有杀菌作用。各菌株之间无显著差异。没有可测量的接种量效应。存活动力学分析显示，5分钟时杀灭率为60%，约2小时时杀灭率为99.9%。奥蒂多硼酸溶液是一种有效的抗铜绿假单胞菌药物。没有证据表明从潜水员分离出的菌株耐药性增加。与常规预防建议相关的杀灭率表明，频繁滴注可能更有效。应评估奥蒂多硼酸溶液在饱和潜水中的治疗用途，以避免不必要地使用抗生素滴剂。
