Ikeda K, Takasaka T
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Am J Otol. 1993 Mar;14(2):170-1.
Five types of ear drops were each assessed for effectiveness on the basis of the in vitro antibacterial activity. Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Pseudomonas aeruginosa isolated from purulent otitis media were evaluated by comparative analysis. Otic drops containing new fluorinated quinolones, Ofloxacin and NY-198, showed high in vitro activity against all the bacteria. Cortisporin expressed moderate activity against P. aeruginosa and relatively weak activity against S. aureus and MRSA. Bestron and Fosmicin possessed low activity against three clinical isolates. Otic drops containing the new quinolones may be effective for treating purulent otitis media infected by MRSA and P. aeruginosa.
根据体外抗菌活性对五种类型的耳滴剂的有效性进行了评估。通过比较分析对从化脓性中耳炎分离出的金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌（MRSA）和铜绿假单胞菌进行了评估。含有新型氟化喹诺酮类药物氧氟沙星和NY-198的耳滴剂对所有细菌均显示出高体外活性。可的霉素对铜绿假单胞菌表现出中等活性，而对金黄色葡萄球菌和MRSA的活性相对较弱。百士特和磷霉素对三种临床分离株的活性较低。含有新型喹诺酮类药物的耳滴剂可能对治疗由MRSA和铜绿假单胞菌感染引起的化脓性中耳炎有效。
