Guo Zheng, Zheng Yulu, Geng Jian, Wu Zhiyuan, Wei Tao, Shan Guangle, Zhu Yahong, Zheng Yuanyuan, Li Xingang
Centre for Precision Health, Edith Cowan University, Perth, Australia.
Department of Clinical Laboratory, Tai'an City Public Health Medical Center, Tai'an, China.
J Clin Neurosci. 2024 Jan;119:45-51. doi: 10.1016/j.jocn.2023.11.004. Epub 2023 Nov 17.
This study aimed to evaluate the association between systemic inflammation markers and cognitive performance among older US adults.
This cross-sectional study assessed 3,632 older participants from the 2011-2014 National Health and Nutrition Examination Survey (NHANES). The main analysis included participants aged over 60 years. Systemic inflammation markers were quantified by calculating the composite inflammation indicators from the blood routine count, and cognitive performance was assessed using Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST).
There were 2,743 individuals enrolled in the current analysis. The overall mean age was 64.9 years and 48.7 % were males. The levels of SIRI and PIV were significant negative associated with scores of CERAD, CERAD delayed recall, and DSST in the unadjusted models. Moreover, SII were significant negative associated with scores of CERAD and CERAD delayed recall. After adjusting the covariates of demographics, lifestyle factors, history of chronic diseases and BMI, significant negative association were observed between systematic inflammation markers and cognitive performance. Additionally, a progressive and significant decrease in the score of cognitive performance assessments with the increased levels of SIRI, SII, and PIV were respectively observed. Finally, the correlation between systemic inflammation markers and cognitive performance were evidenced in the sensitive analysis.
Findings support a strong inverse correlation between systemic inflammation markers and cognitive performance, suggesting that addressing inflammation could be a promising avenue for enhancing cognitive health and mitigating age-related cognitive decline.
本研究旨在评估美国老年成年人全身炎症标志物与认知表现之间的关联。
这项横断面研究评估了来自2011 - 2014年美国国家健康与营养检查调查（NHANES）的3632名老年参与者。主要分析纳入了60岁以上的参与者。通过计算血常规计数得出的综合炎症指标来量化全身炎症标志物，并使用阿尔茨海默病注册协会（CERAD）测试、动物流畅性测试（AFT）和数字符号替换测试（DSST）来评估认知表现。
本分析纳入了2743名个体。总体平均年龄为64.9岁，男性占48.7%。在未调整模型中，SIRI和PIV水平与CERAD、CERAD延迟回忆及DSST得分呈显著负相关。此外，SII与CERAD及CERAD延迟回忆得分呈显著负相关。在调整了人口统计学、生活方式因素、慢性疾病史和BMI等协变量后，观察到全身炎症标志物与认知表现之间存在显著负相关。此外，分别观察到随着SIRI、SII和PIV水平升高，认知表现评估得分呈渐进性显著下降。最后，敏感性分析证实了全身炎症标志物与认知表现之间的相关性。
研究结果支持全身炎症标志物与认知表现之间存在强烈的负相关，表明解决炎症问题可能是促进认知健康和减轻与年龄相关的认知衰退的一个有前景的途径。
