来自秀丽斑种草的倍半萜类化合物具有抗三阴性乳腺癌和抗菌活性。
Meroterpenoids with anti-triple negative breast cancer and antimicrobial activities from Arnebia euchroma.
机构信息
Faculty of Materials and Chemical Engineering, Yibin University, Yibin 644000, China.
Faculty of Materials and Chemical Engineering, Yibin University, Yibin 644000, China; Evaluation and Research Center of Daodi Herbs of Jiangxi Province, Ganjiang New District 330000, China.
出版信息
Fitoterapia. 2024 Dec;179:106234. doi: 10.1016/j.fitote.2024.106234. Epub 2024 Sep 26.
Two new meroterpenoids, arneuchrols A and B (1 and 2), together with twelve known analogs (3-14) were isolated from the root of Arnebia euchroma. The structures of 1 and 2 including their absolute configurations were elucidated by NMR, HRESIMS, and DFT calculation of their NMR and ECD data. The structure of pseudoshikonin I, firstly isolated from Lithospermi radix was revised as shikonofuran E (4). Anti-triple negative breast cancer (anti-TNBC) and antimicrobial activities of the isolated compounds were tested. Compounds 3, 4, 6, 7, 9, 10, and 13 exhibited potent inhibitory activity against TNBC (MDA-MB-231 cells) with IC values in the range of 0.18-4.58 μM. Compound 10 displayed antifungal activity against five plant pathogenic fungi with MIC values in the range of 6.25-25 μg/mL. Compound 9 exhibited antibacterial activity against Micrococcus lysodeikticus with MIC value of 12.5 μg/mL.
从新疆紫草中分离得到了两个新的倍半萜类化合物arneuchrols A 和 B（1 和 2），以及 12 个已知类似物（3-14）。通过 NMR、HRESIMS 和 DFT 计算其 NMR 和 ECD 数据，阐明了 1 和 2 的结构，包括它们的绝对构型。首次从紫草中分离得到的伪紫草素 I 的结构被修订为紫草呋喃 E（4）。对分离得到的化合物进行了抗三阴性乳腺癌（anti-TNBC）和抗微生物活性测试。化合物 3、4、6、7、9、10 和 13 对 TNBC（MDA-MB-231 细胞）具有较强的抑制活性，IC 值范围为 0.18-4.58 μM。化合物 10 对五种植物病原菌真菌具有抗真菌活性，MIC 值范围为 6.25-25 μg/mL。化合物 9 对溶壁微球菌具有抗菌活性，MIC 值为 12.5 μg/mL。
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