从鸡屎藤中分离得到的三个新的细胞毒倍半萜类化合物 Pogostemins A-C。
Pogostemins A-C, three new cytotoxic meroterpenoids from Pogostemon auricularius.
机构信息
Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Viet Nam.
Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City, Viet Nam; National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem District, Ha Noi, Viet Nam.
出版信息
Fitoterapia. 2018 Oct;130:100-104. doi: 10.1016/j.fitote.2018.08.015. Epub 2018 Aug 23.
Pogostemins A-C (1-3), three new meroterpenoids with pyrone-sesquiterpenoid hybrid skeletons, were isolated from the aerial parts of Pogostemon auricularius. Their chemical structures were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 1 showed significant cytotoxicities against the human colon adenocarcinoma SW-480, epidermoid carcinoma KB, gastric cancer AGS, hepatoma cancer Hep-G2, and lung cancer LU-1 cell lines with IC values of 7.21, 8.49, 9.44, 11.75, and 12.76 μg/mL, respectively.
从 Pogostemon auricularius 的地上部分分离得到了三个新的倍半萜-吡喃酮类化合物 Pogostemins A-C (1-3)。通过 1D 和 2D-NMR 和 HRESIMS 分析确定了它们的化学结构。化合物 1 对人结肠腺癌 SW-480、表皮样癌细胞 KB、胃癌 AGS、肝癌 Hep-G2 和肺癌 LU-1 细胞系具有显著的细胞毒性，IC 值分别为 7.21、8.49、9.44、11.75 和 12.76μg/mL。
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