Cohen W A, Young W, DeCrescito V, Horii S, Kricheff I I
AJNR Am J Neuroradiol. 1985 Sep-Oct;6(5):823-7.
An experimental study was performed to examine posttraumatic spinal cord cavitation in an animal model by evaluating immediate and delayed computed tomographic (CT) scans obtained after administration of intrathecal contrast material. Four cats underwent midthoracic laminectomy and spinal cord contusion using a standard 400 g-cm model. All animals were studied by CT with intrathecal contrast enhancement before and 4-5 days, 3-4 weeks, and 7-13 weeks after experimental cord contusion. Either metrizamide or iopamidol was used as the contrast agent. Two of the four cats had CT and pathologic evidence of cord cavitation at the site of injury. Another animal had uptake of contrast material into the spinal cord without pathologic evidence of cyst formation, which was believed to represent malacic change. The fourth animal had a normal-appearing cord by both CT and pathologic criteria. Animals that received metrizamide after cord contusion had generalized myoclonic seizures. This did not occur when iopamidol was administered.
进行了一项实验研究，通过评估鞘内注入造影剂后即刻及延迟计算机断层扫描（CT），在动物模型中研究创伤后脊髓空洞形成情况。4只猫采用标准的400 g-cm模型接受胸段中段椎板切除术和脊髓挫伤。在实验性脊髓挫伤前以及挫伤后4 - 5天、3 - 4周和7 - 13周，对所有动物进行鞘内造影增强CT检查。使用甲泛葡胺或碘帕醇作为造影剂。4只猫中有2只在损伤部位有脊髓空洞形成的CT及病理证据。另一只动物脊髓有造影剂摄取，但无囊肿形成的病理证据，这被认为代表软化改变。第四只动物根据CT和病理标准显示脊髓外观正常。脊髓挫伤后接受甲泛葡胺的动物出现全身性肌阵挛性癫痫发作。给予碘帕醇时未发生这种情况。
