老年男性睾丸体外内分泌功能受损。

Impaired in vitro testicular endocrine function in elderly men.

作者信息

Hammar M

出版信息

Andrologia. 1985 Sep-Oct;17(5):444-9. doi: 10.1111/j.1439-0272.1985.tb01039.x.

DOI:10.1111/j.1439-0272.1985.tb01039.x

Abstract

Measurements of testosterone concentrations in peripheral and spermatic venous blood have yielded conflicting results concerning testosterone production in elderly men. To further elucidate the testicular endocrine capacity during aging, peripheral serum hormone levels and the in vitro conversion of progesterone and pregnenolone in histopathologically normal testicular tissue have been investigated in 22 elderly men and 28 younger adult males. The conversion mediated by 3 beta-hydroxysteroid-dehydrogenase and 17 alpha-hydroxylase was significantly higher (p less than 0.05 and p less than 0.01 respectively) in testicular tissue from the younger adult men, than in testicular tissue from elderly men. Since serum LH levels were significantly higher (p less than 0.01) and serum testosterone levels were significantly lower (p less than 0.01) in the elderly men, these data indicate that there was a primary endocrine impairment at the testicular level in the elderly men.

摘要

对外周血和精索静脉血中睾酮浓度的测量，在老年男性睾酮生成方面得出了相互矛盾的结果。为了进一步阐明衰老过程中睾丸的内分泌能力，对22名老年男性和28名年轻成年男性的外周血清激素水平以及组织病理学正常的睾丸组织中孕酮和孕烯醇酮的体外转化情况进行了研究。在年轻成年男性的睾丸组织中，由3β-羟基类固醇脱氢酶和17α-羟化酶介导的转化显著更高（分别为p<0.05和p<0.01），高于老年男性的睾丸组织。由于老年男性的血清促黄体生成素水平显著更高（p<0.01），而血清睾酮水平显著更低（p<0.01），这些数据表明老年男性在睾丸水平存在原发性内分泌损害。