Digestive Endoscopic Center, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Central Lab, School of Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
BMC Gastroenterol. 2024 Sep 27;24(1):324. doi: 10.1186/s12876-024-03426-1.
Gallstone disease poses a global threat to human health and is strongly linked to environmental factors. However, there is currently no data on the presence of rare earth elements (REEs) in human gallstones. This paper investigates the concentration and distribution of REEs in gallstones for the first time, aiming to explore the environmental implications on human health.
A total of 25 gallstone samples were collected in Shanghai and the content of REEs was measured by Inductively coupled plasma-Mass Spectrometry (ICP-MS) to explore the distribution of REEs in gallstones.
The concentration of REEs in gallstones ranged from 4.89 to 190.8 ng/g (mean 39.21). In most of the gallstone analyses, REEs have been detected and generally attributed to environmental exposure or food contamination. The Y/Ho ratio of gallstones was lower than that of continental rocks, similar to that in the blood, indicating limited fractionation during fluid transport processes in the gallbladder.
The upper continental crust (UCC)-normalized REEs pattern in gallstones showed depletion of light REEs, while most showed enrichment of heavy REEs. Positive Gd anomalies were found in most samples, while few samples suggested anthropogenic influence. Whether exogenous inputs or in vivo biofractionation lead to changes in REEs fractionated patterns require further analyses.
胆石病对全球人类健康构成威胁，与环境因素密切相关。然而，目前尚无人类胆石中存在稀土元素（REEs）的数据。本文首次研究胆石中 REEs 的浓度和分布，旨在探讨其对人类健康的环境影响。
共采集上海 25 例胆石样本，采用电感耦合等离子体质谱法（ICP-MS）测量 REEs 含量，探讨胆石中 REEs 的分布。
胆石中 REEs 的浓度范围为 4.89-190.8ng/g（均值 39.21）。在大多数胆石分析中，已检测到 REEs，通常归因于环境暴露或食物污染。胆石的 Y/Ho 比值低于大陆岩石，与血液相似，表明在胆囊流体传输过程中有限的分馏。
胆石的上地壳（UCC）归一化 REEs 模式显示轻 REEs 的亏损，而大多数显示重 REEs 的富集。大多数样本中存在正的 Gd 异常，而少数样本表明存在人为影响。REEs 分馏模式的变化是由外源性输入还是体内生物分馏引起，需要进一步分析。
