代谢综合征及其成分与年龄相关性白内障的相关性存在性别差异：韩国 2008-2010 年国家健康和营养检查调查。
Gender difference in the association of metabolic syndrome and its components with age-related cataract: the Korea National Health and Nutrition Examination Survey 2008-2010.
机构信息
Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea ; Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
PLoS One. 2014 Jan 8;9(1):e85068. doi: 10.1371/journal.pone.0085068. eCollection 2014.
PURPOSE
To explore the relationship of the metabolic syndrome (MetS) and its components with age-related cataract in a representative Korean population.
METHODS
We analyzed the data from the Korea National Health and Nutrition Examination Surveys (2008-2010). A total of 11,076 adults (4,811 men and 6,265 women) aged 40 and over who completed ophthalmologic examination were evaluated. Cataract was defined as the presence of cortical, nuclear, anterior (sub)capsular or posterior subcapsular cataract, from slit-lamp examination or previous cataract surgery. MetS was defined according to the Joint Interim Statement proposed in 2009 from the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute.
RESULTS
The prevalence of cataract and MetS in this population was 39.4% (37.1% for men and 41.6% for women) and 38.5% (37.6% for men and 39.4% for women), respectively. Cataract prevalence tended to increase with the number of MetS components in both genders (both P< 0.001). After being controlled for confounders, however, MetS was significantly associated with cataract only in women (adjusted odds ratio (aOR), 1.24; 95% confidence interval (CI), 1.02-1.50]. Reduced HDL cholesterol, elevated fasting glucose, and elevated triglycerides were also significantly associated with cataract in women (aOR, 95% CI; 1.27 (1.07-1.50), 1.23 (1.01-1.50), and 1.26 (1.04-1.52), respectively). In the subgroup analysis for cataract subtype, MetS and reduced HDL cholesterol were significantly associated with nuclear cataract in women (aOR, 95% CI; 1.25 (1.07-1.55) and 1.25 (1.03-1.52), respectively). However, such associations were not found in men.
CONCLUSIONS
Our results suggest that MetS and its components appear to be associated with age-related cataract only among Korean women, especially in nuclear cataract.
目的
在具有代表性的韩国人群中，探讨代谢综合征（MetS）及其各组分与年龄相关性白内障之间的关系。
方法
我们对 2008-2010 年韩国国家健康和营养检查调查（Korean National Health and Nutrition Examination Surveys，KNHANES）的数据进行了分析。共纳入了 11076 名年龄在 40 岁及以上、完成眼科检查的成年人（男性 4811 名，女性 6265 名）。白内障定义为裂隙灯检查或既往白内障手术后皮质性、核性、前（囊下）皮质性或后囊下白内障的存在。MetS 按照国际糖尿病联合会（International Diabetes Federation）和美国心脏协会/美国国立心肺血液研究所（American Heart Association/National Heart, Lung, and Blood Institute）于 2009 年提出的联合临时声明进行定义。
结果
在该人群中，白内障和 MetS 的患病率分别为 39.4%（男性为 37.1%，女性为 41.6%）和 38.5%（男性为 37.6%，女性为 39.4%）。无论男性还是女性，白内障的患病率均随 MetS 组分数量的增加而升高（均 P<0.001）。然而，在校正混杂因素后，MetS 仅与女性的白内障显著相关（调整后的优势比（adjusted odds ratio，aOR）为 1.24；95%置信区间（confidence interval，CI）为 1.02-1.50]）。在女性中，低水平高密度脂蛋白胆固醇、空腹血糖升高和甘油三酯升高也与白内障显著相关（aOR，95%CI；1.27（1.07-1.50）、1.23（1.01-1.50）和 1.26（1.04-1.52））。在白内障亚型的亚组分析中，MetS 和低水平高密度脂蛋白胆固醇与女性的核性白内障显著相关（aOR，95%CI；1.25（1.07-1.55）和 1.25（1.03-1.52））。然而，在男性中未发现这些关联。
结论
我们的研究结果表明，MetS 及其各组分似乎仅与韩国女性的年龄相关性白内障相关，尤其是与核性白内障相关。
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