长期暴露于颗粒物与心血管疾病之间的 TyG 相关指标的中介效应：来自全国纵向队列研究的证据。
The mediating effect of TyG-related indicators between long-term exposure to particulate matter and cardiovascular disease: evidence from a national longitudinal cohort study.
机构信息
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
Zhejiang International Science and Technology Cooperation Base of Air Pollution and Health, Hangzhou, China.
出版信息
Lipids Health Dis. 2024 Sep 27;23(1):319. doi: 10.1186/s12944-024-02305-8.
BACKGROUND
Ambient particulate matter (PM) exposure is recognized as a risk factor for cardiovascular disease (CVD). However, the extent to which PM exposure is associated with CVD via triglyceride glucose (TyG)-related indicators remains unknown. This study examines the relationship between long-term PM exposure and CVD events, further assessing whether TyG-related indicators mediate this association.
METHODS
This cohort study involved 7,532 individuals aged at least 45 years who were not diagnosed with CVD in 2011 from the China Longitudinal Study of Health and Retirement (CHARLS) and were followed up for the occurrence of CVD until 2020. The annual PM concentration data at the city level, with aerodynamic diameters ≤ 1 μm (PM), ≤ 2.5 μm (PM), and ≤ 10 μm (PM), were obtained from the ChinaHighAirPollutants (CHAP). The average concentration of PM in the 3 years before the baseline survey in 2011 was defined as the long-term exposure level of the individual. The relationship between PM exposure and CVD incidence was examined via Cox proportional hazards models, with a focus on probing the role of TyG-related indicators through mediation analysis.
RESULTS
A total of 1,865 individuals with CVD were diagnosed over the span of a 7.4-year follow-up period. The 3-year average concentrations before baseline were 31.29 µg/m³ for PM, 56.03 µg/m³ for PM, and 95.73 µg/m³ for PM. In fully adjusted model, the Cox proportional hazards models revealed that an increase of 10 µg/m³ in the PM, PM, and PM exposure concentrations corresponded to elevated CVD risk, with HRs (95% CI) of 1.135 (1.078-1.195), 1.092 (1.062-1.123), and 1.075 (1.059-1.090), respectively. Mediation analyses further suggested that the correlation between PM exposure and CVD could be partly mediated via TyG-BMI, TyG-WC, and TyG-WHtR, with mediation proportions varying from 5.54 to 15.30%.
CONCLUSION
A significant correlation was observed between long-term PM exposure and increased CVD risk, with TyG-related indicators, such as TyG-BMI, TyG-WC, and TyG-WHtR, partially mediating this relationship.
背景
环境颗粒物（PM）暴露已被确认为心血管疾病（CVD）的危险因素。然而，PM 暴露与 CVD 之间通过甘油三酯-葡萄糖（TyG）相关指标的关联程度尚不清楚。本研究旨在探讨长期 PM 暴露与 CVD 事件之间的关系，并进一步评估 TyG 相关指标是否在其中起中介作用。
方法
本队列研究纳入了 2011 年来自中国健康与养老追踪调查（CHARLS）中年龄至少为 45 岁且无 CVD 诊断的 7532 名个体，并随访至 2020 年发生 CVD 为止。城市水平的 PM 浓度年数据（空气动力学直径≤1μm（PM）、≤2.5μm（PM）和≤10μm（PM））来自中国高空气污染物（CHAP）项目。2011 年基线调查前 3 年的 PM 平均浓度被定义为个体的长期暴露水平。采用 Cox 比例风险模型来检验 PM 暴露与 CVD 发病之间的关系，并通过中介分析重点探讨 TyG 相关指标的作用。
结果
在 7.4 年的随访期间，共有 1865 人被诊断出患有 CVD。基线前 3 年的平均浓度分别为 PM 为 31.29μg/m³，PM 为 56.03μg/m³，PM 为 95.73μg/m³。在完全调整的模型中，Cox 比例风险模型显示，PM、PM 和 PM 暴露浓度每增加 10μg/m³，CVD 风险分别升高 1.135（1.078-1.195）、1.092（1.062-1.123）和 1.075（1.059-1.090）。中介分析进一步表明，PM 暴露与 CVD 之间的相关性部分可通过 TyG-BMI、TyG-WC 和 TyG-WHtR 进行中介，中介比例在 5.54%至 15.30%之间。
结论
长期 PM 暴露与 CVD 风险增加显著相关，TyG 相关指标（如 TyG-BMI、TyG-WC 和 TyG-WHtR）部分介导了这种关系。
Zotero 插件