1型糖尿病中的肾小管功能障碍。
Tubular dysfunction in type I diabetes mellitus.
作者信息
Miltényi M, Körner A, Tulassay T, Szabó A
出版信息
Arch Dis Child. 1985 Oct;60(10):929-31. doi: 10.1136/adc.60.10.929.
Abstract
Tubular function was investigated in patients with diabetic ketoacidosis and those with poorly controlled type I diabetes. Urinary excretion of beta 2 microglobulin and that of certain enzymes: gamma glutamyltransferase, leucine aminopeptidase, and N-acetyl-beta-D-glucosaminidase activities were significantly raised during ketoacidosis in 11 patients compared with healthy controls. In 13 poorly controlled diabetics, tubular electrolyte transport was studied and a significant reduction in tubular phosphate and sodium reabsorption was found. Tubular dysfunction occurring during diabetic ketoacidosis and in poorly controlled diabetics may contribute to the development of diabetic nephropathy.
摘要
对糖尿病酮症酸中毒患者和1型糖尿病控制不佳的患者的肾小管功能进行了研究。与健康对照组相比，11例酮症酸中毒患者的β2微球蛋白尿排泄量以及某些酶的活性：γ-谷氨酰转移酶、亮氨酸氨肽酶和N-乙酰-β-D-葡萄糖苷酶活性显著升高。在13例控制不佳的糖尿病患者中，研究了肾小管电解质转运，发现肾小管对磷酸盐和钠的重吸收显著减少。糖尿病酮症酸中毒期间和控制不佳的糖尿病患者中出现的肾小管功能障碍可能会促进糖尿病肾病的发展。
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