Pálla Tamás, Noszál Béla, Mirzahosseini Arash
Department of Pharmaceutical Chemistry, Semmelweis University, 1092 Budapest, Hungary.
Center for Pharmacology and Drug Research & Development, Semmelweis University, 1085 Budapest, Hungary.
Antioxidants (Basel). 2024 Aug 29;13(9):1053. doi: 10.3390/antiox13091053.
The principal reactions that maintain redox homeostasis in living systems are the deprotonation of thiols, followed by the oxidative conversion of the produced thiolates into disulfides, which thus reduce the harmful oxidizing agents. The various biological thiols have different molecule-specific propensities to carry on the co-dependent deprotonation and redox processes. This study utilizes the known correlation between thiolate basicities and oxidizabilities, to quantify antioxidant or reducing capacities and pH-dependences of thiol-disulfide antioxidant systems, as a tool to find adequate molecules against oxidative stress.
维持生物系统氧化还原稳态的主要反应是硫醇的去质子化，随后生成的硫醇盐被氧化转化为二硫键，从而还原有害的氧化剂。各种生物硫醇在进行相互依赖的去质子化和氧化还原过程时具有不同的分子特异性倾向。本研究利用硫醇盐碱度和氧化能力之间的已知相关性，来量化硫醇 - 二硫键抗氧化系统的抗氧化或还原能力以及pH依赖性，作为寻找对抗氧化应激的合适分子的一种工具。
