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噬菌体疗法对体外伤口模型的作用及与β-内酰胺类抗生素联合使用的协同效应

Bacteriophage Therapy on an In Vitro Wound Model and Synergistic Effects in Combination with Beta-Lactam Antibiotics.

作者信息

Santamaría-Corral Guillermo, Aguilera-Correa John Jairo, Esteban Jaime, García-Quintanilla Meritxell

机构信息

Clinical Microbiology Department, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, 28040 Madrid, Spain.

CIBERINFEC-Consorcio Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas, 28029 Madrid, Spain.

出版信息

Antibiotics (Basel). 2024 Aug 24;13(9):800. doi: 10.3390/antibiotics13090800.

DOI:10.3390/antibiotics13090800
PMID:39334975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11428794/
Abstract

One of the primary opportunistic pathogens that can cause a wide range of diseases is . This microorganism can become resistant to practically every antibacterial currently in use, including beta-lactam antibiotics. Its ability to proliferate as biofilm has been linked to, among other things, the failure of antimicrobial therapies. Due to a variety of virulence factors and host immune system modifications, is one of the most significant and common bacteria that colonize wounds and burns. A novel therapeutic option for treating these multidrug-resistant (MDR) bacterial infections is the combination of antibiotics and bacteriophages. This approach has been linked to improved biofilm penetration, a decreased selection of antibiotic and bacteriophage resistance, and an enhanced antibacterial impact. Combining the F1Pa bacteriophage and beta-lactam antibiotics reduced the viability of the mature biofilm of MDR strains and suppressed bacterial growth in vitro. F1Pa critically reduced the amount of biofilm that MDR clinical strains formed in the in vitro wound model. These findings highlight the bacteriophage F1Pa's therapeutic potential as a prophylactic topical treatment against MDR pseudomonal infections in wounds and burns.

摘要

一种可引发多种疾病的主要机会性病原体是 。这种微生物几乎能对目前使用的每种抗菌药物产生耐药性，包括β-内酰胺类抗生素。其形成生物膜进行增殖的能力，除其他因素外，与抗菌治疗的失败有关。由于多种毒力因子和宿主免疫系统的改变， 是在伤口和烧伤处定植的最重要且最常见的细菌之一。治疗这些多重耐药（MDR）细菌感染的一种新的治疗选择是抗生素与噬菌体的联合使用。这种方法与改善生物膜穿透性、减少抗生素和噬菌体耐药性的选择以及增强抗菌作用有关。将F1Pa噬菌体与β-内酰胺类抗生素联合使用可降低MDR 菌株成熟生物膜的活力，并在体外抑制细菌生长。F1Pa显著减少了MDR 临床菌株在体外伤口模型中形成的生物膜量。这些发现突出了噬菌体F1Pa作为预防伤口和烧伤中MDR假单胞菌感染的局部治疗药物的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dae/11428794/cbc4ed501090/antibiotics-13-00800-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dae/11428794/811c3328ffbb/antibiotics-13-00800-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dae/11428794/4c2f6b0d7d22/antibiotics-13-00800-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dae/11428794/007ae715653d/antibiotics-13-00800-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dae/11428794/0c00bd682b4b/antibiotics-13-00800-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dae/11428794/811c3328ffbb/antibiotics-13-00800-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2dae/11428794/cbc4ed501090/antibiotics-13-00800-g010.jpg

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本文引用的文献

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A Novel Bacteriophage Infecting Multi-Drug- and Extended-Drug-Resistant Strains.一种感染多重耐药和广泛耐药菌株的新型噬菌体。
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Exploiting phage-antibiotic synergies to disrupt PAO1 biofilms in the context of orthopedic infections.利用噬菌体-抗生素协同作用破坏骨科感染背景下的 PAO1 生物膜。
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Combining phages and antibiotic to enhance antibiofilm efficacy against an dual species wound biofilm.
联合使用噬菌体和抗生素以增强对双菌种伤口生物膜的抗生物膜功效。
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Class-Driven Synergy and Antagonism between a Pseudomonas Phage and Antibiotics.基于类别的噬菌体与抗生素协同与拮抗作用
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Bacteriophages: The promising therapeutic approach for enhancing ciprofloxacin efficacy against bacterial infection.噬菌体：增强环丙沙星治疗细菌感染疗效的有前途的治疗方法。
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Phage-resistant against a novel lytic phage JJ01 exhibits hypersensitivity to colistin and reduces biofilm production.对新型裂解性噬菌体JJ01具有抗性的菌株对黏菌素表现出超敏反应并减少生物膜的产生。
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Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.噬菌体-抗生素联合治疗广泛耐药铜绿假单胞菌感染，以实现婴幼儿肝移植。
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