牛磺罗定抗菌封管在预防接受肠外营养儿童导管相关血流感染（CRBSIs）中的有效性：病例系列
The Effectiveness of Taurolidine Antimicrobial Locks in Preventing Catheter-Related Bloodstream Infections (CRBSIs) in Children Receiving Parenteral Nutrition: A Case Series.
作者信息
Ling Galina, Ben-Shimol Shalom, Elamour Siham, Nassar Raouf, Kristal Eyal, Shalev Rotem, Howard Gadi, Yerushalmi Baruch, Kogan Slava, Shmueli Moshe
机构信息
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.
The Pediatric Day-Care Unit, Soroka University Medical Center, Beer-Sheva 84101, Israel.
出版信息
Antibiotics (Basel). 2024 Sep 5;13(9):847. doi: 10.3390/antibiotics13090847.
INTRODUCTION
We assessed the efficacy of taurolidine lock (TL) in preventing catheter-related bloodstream infections (CRBSIs) and related hospitalizations in children with parenteral nutrition (PN) in the home setting.
METHODS
This study is a retrospective case series study. All children with intestinal failure in a single center in southern Israel who were administered PN and treated with TL between 2017 and 2024 were included. The rates of CRBSI episodes, related hospitalizations and pathogen distribution in the pre-TL and post-TL periods were compared.
RESULTS
Overall, 14 patients were included. The median pre-TL and post-TL periods were 990 and 1260 days, respectively. The rate of CRBSI episodes due to bacterial infection per 1000 days declined by 45%, from 6.2 to 3.7, with = 0.0008, while fungal CRBSI rates were low (<10% of all positive cultures) and did not decline significantly. Similarly, the hospitalization episode rate per 1000 days declined by 41%, from 7.6 to 4.5, with = 0.001.
CONCLUSIONS
Taurolidine lock treatment for children with central-line PN resulted in a substantial decrease in CRBSI episodes and related hospitalizations.
引言
我们评估了牛磺罗定封管（TL）在预防居家接受肠外营养（PN）的儿童发生导管相关血流感染（CRBSI）及相关住院方面的疗效。
方法
本研究为回顾性病例系列研究。纳入了2017年至2024年间在以色列南部单一中心接受PN并采用TL治疗的所有肠衰竭儿童。比较了TL使用前和使用后CRBSI发作率、相关住院率及病原体分布情况。
结果
总共纳入了14例患者。TL使用前和使用后的中位时间分别为990天和1260天。每1000天细菌感染导致的CRBSI发作率下降了45%，从6.2降至3.7，P = 0.0008，而真菌性CRBSI发生率较低（<所有阳性培养物的10%）且无显著下降。同样，每1000天的住院发作率下降了41%，从7.6降至4.5，P = 0.001。
结论
对接受中心静脉PN的儿童进行牛磺罗定封管治疗可显著降低CRBSI发作率及相关住院率。
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