碳、氮和硫的同位素组成作为子宫内膜癌的一个指标
Isotopic Composition of C, N, and S as an Indicator of Endometrial Cancer.
作者信息
Zuzak Tomasz, Bogaczyk Anna, Krata Agnieszka Anna, Kamiński Rafał, Paneth Piotr, Kluz Tomasz
机构信息
Department of Gynecology, Gynecology Oncology and Obstetrics, Fryderyk Chopin University Hospital, Szopena 2, 35-055 Rzeszow, Poland.
Institute of Applied Radiation Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
出版信息
Cancers (Basel). 2024 Sep 16;16(18):3169. doi: 10.3390/cancers16183169.
OBJECTIVES
The metabolic pathway of cancerous tissue differs from healthy tissue, leading to the unique isotopic composition of stable isotopes at their natural abundance. We have studied if these changes can be developed into diagnostic or prognostic tools in the case of endometrial cancer.
METHODS
Measurements of stable isotope ratios were performed using isotope ratio mass spectrometry for nitrogen, carbon, and sulfur isotopic assessment. Uterine tissue and serum samples were collected from patients and the control group.
RESULTS
At a natural abundance, the isotopic compositions of all three of the studied elements of uterus cancerous and healthy tissues are different. However, no correlation of the isotopic composition of the tissues with that of serum was found.
CONCLUSIONS
Differences in the isotopic composition of the tissues might be a potential prognostic tool. However, the lack of a correlation between the differences in the isotopic composition of the tissues and serum seems to exclude their application as diagnostic biomarkers, which, however, might be possible if a position-specific isotopic analysis is performed.
目的
癌组织的代谢途径与健康组织不同，导致其天然丰度下稳定同位素的独特同位素组成。我们研究了在子宫内膜癌病例中，这些变化是否可发展为诊断或预后工具。
方法
使用同位素比率质谱法对氮、碳和硫进行同位素评估，以测量稳定同位素比率。从患者和对照组收集子宫组织和血清样本。
结果
在天然丰度下，子宫癌组织和健康组织中所有三种研究元素的同位素组成均不同。然而，未发现组织的同位素组成与血清的同位素组成之间存在相关性。
结论
组织同位素组成的差异可能是一种潜在的预后工具。然而，组织同位素组成差异与血清之间缺乏相关性似乎排除了将其用作诊断生物标志物的可能性，不过，如果进行位置特异性同位素分析，这或许是可行的。
Zotero 插件