Gavrilovic Aleksandar, Gavrilovic Jagoda, Ilic Zivojinovic Jelena, Jeličić Ljiljana, Radovanovic Snezana, Vesic Katarina
Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Clinic of Neurology, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia.
Brain Sci. 2024 Aug 26;14(9):858. doi: 10.3390/brainsci14090858.
The presence of anxiety in individuals with epilepsy significantly influences their medical treatment and quality of life and often goes unrecognized or untreated, posing a challenge to differential diagnosis. The study aimed to investigate the influence of epilepsy characteristics on anxiety. The research involved 155 patients with generalized and focal drug-sensitive [DSE] and drug-resistant [DRE] epilepsy. Hamilton anxiety rating scale [HAS] was used to assess the symptoms of anxiety at three time points [baseline, 12, and 18 months]. DSE patients exhibited significantly lower HAM-A scores than patients with DRE at the initial visit [ = 0.000] after 12 [ = 0.000] and 18-month follow-up [ = 0.000]. Focal DRE patients presented higher HAM-A scores than focal DSE patients in the initial visit [ = 0.000] after 12 [ = 0.000] and 18 months [ = 0.000]. Medication responsiveness, seizure type, and illness duration emerged as significant anxiety predictors [ = 0.000]. After 18 months of follow-up, significant contributors to anxiety were drug responsivity and illness duration [ = 0.000]. The occurrence of anxiety in epilepsy patients is most significantly influenced by well-controlled epilepsy and a positive response to medication.
癫痫患者中焦虑症的存在会显著影响其医疗治疗和生活质量，且常常未被识别或治疗，这给鉴别诊断带来了挑战。该研究旨在调查癫痫特征对焦虑症的影响。该研究涉及155例全身性和局灶性药物敏感性癫痫[DSE]和药物抵抗性癫痫[DRE]患者。使用汉密尔顿焦虑评定量表[HAS]在三个时间点[基线、12个月和18个月]评估焦虑症状。在初次就诊时[P = 0.000]、12个月随访后[P = 0.000]和18个月随访后[P = 0.000]，DSE患者的HAM - A评分显著低于DRE患者。局灶性DRE患者在初次就诊时[P = 0.000]、12个月后[P = 0.000]和18个月后[P = 0.000]的HAM - A评分高于局灶性DSE患者。药物反应性、癫痫发作类型和病程成为显著的焦虑预测因素[P = 0.000]。随访18个月后，焦虑的重要促成因素是药物反应性和病程[P = 0.000]。癫痫患者焦虑症的发生受癫痫良好控制和药物阳性反应的影响最为显著。
