轻度创伤性脑损伤中具有临床意义的睡眠障碍风险增加：利用联邦跨部门创伤性脑损伤研究数据库的方法。

Increased Risk for Clinically Significant Sleep Disturbances in Mild Traumatic Brain Injury: An Approach to Leveraging the Federal Interagency Traumatic Brain Injury Research Database.

作者信息

O'Neil Maya E, Krushnic Danielle, Walker William C, Cameron David, Baker-Robinson William, Hannon Sara, Clauss Kate, Cheney Tamara P, Cook Lawrence J, Niederhausen Meike, Kaplan Josh, Pappas Miranda, Martin Aaron M

机构信息

HSR Center to Improve Veteran Involvement in Care (CIVIC), Portland VA Health Care System, Portland, OR 97239, USA.

Department of Clinical Psychiatry, Oregon Health & Science University, Portland, OR 97239, USA.

出版信息

Brain Sci. 2024 Sep 14;14(9):921. doi: 10.3390/brainsci14090921.

DOI:10.3390/brainsci14090921

PMID:39335416

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11430117/

Abstract

STUDY OBJECTIVES

The Federal Interagency Traumatic Brain Injury Research (FITBIR) Informatics System contains individual-patient-level traumatic brain injury (TBI) data, which when combined, allows for the examination of rates and outcomes for key subpopulations at risk for developing sleep disturbance.

METHODS

This proof-of-concept study creates a model system for harmonizing data (i.e., combining and standardizing data) across FITBIR studies for participants with and without a history of TBI to estimate rates of sleep disturbance and identify risk factors.

RESULTS

Three studies were eligible for harmonization (N = 1753). Sleep disturbance was common among those with a history of mild TBI (63%). Individuals with mild TBI were two to four times more likely to have sleep disturbance compared to those with no history of TBI.

CONCLUSIONS

This study established methods, harmonization code, and meta-databases that are publicly available on the FITBIR website. We demonstrated how the harmonization of FITBIR studies can answer TBI research questions, showing that associations between TBI and sleep disturbance may be influenced by demographic factors.

摘要