Wickwire Emerson M, Albrecht Jennifer S, Griffin Nicholas R, Schnyer David M, Yue John K, Markowitz Amy J, Okonkwo David O, Valadka Alex B, Badjatia Neeraj, Manley Geoffrey T
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD.
Sleep Disorders Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Curr Neurobiol. 2019 Jul;10(2):49-55.
The purpose of the present study was to evaluate the impact of sleep disturbances on subsequent depressive symptomatology among a representative sample of patients following traumatic brain injury (TBI). Within a retrospective cohort design, our sample included 305 individuals from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot; NINDS-OD09-004) database. At 3-months post-TBI, symptoms of insomnia were reported by 34% of patients, and symptoms of hypersomnia were reported by 39% of patients. For the vast majority of individuals, sleep complaints were likely to persist through 6-month follow-up. Symptoms of hypersomnia but not insomnia at three months were associated with worsened depressive symptomatology at six months. These results highlight the importance of sleep disturbances in recovery from TBI and suggest targeted sleep treatments as a pathway to improve outcomes and quality of life following TBI.
本研究的目的是评估睡眠障碍对创伤性脑损伤（TBI）患者代表性样本中后续抑郁症状的影响。在回顾性队列设计中，我们的样本包括来自创伤性脑损伤转化研究与临床知识试点（TRACK-TBI试点；NINDS-OD09-004）数据库的305名个体。在TBI后3个月，34%的患者报告有失眠症状，39%的患者报告有嗜睡症状。对于绝大多数个体，睡眠问题可能会持续到6个月的随访期。3个月时的嗜睡症状而非失眠症状与6个月时抑郁症状的加重有关。这些结果突出了睡眠障碍在TBI恢复中的重要性，并表明针对性的睡眠治疗是改善TBI后结局和生活质量的一条途径。
