Ke Te-Min, Lophatananon Artitaya, Muir Kenneth R
Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
Biomedicines. 2024 Sep 2;12(9):1985. doi: 10.3390/biomedicines12091985.
DNA methylation, validated as a surrogate for biological age, is a potential tool for predicting future morbidity and mortality outcomes. This study aims to explore how lifestyle patterns are associated with epigenetic changes in British men. Five biological age clocks were utilised to investigate the relationship between these epigenetic markers and lifestyle-related factors in a prospective study involving 221 participants. Spearman's correlation test, Pearson's correlation test, and univariate linear regression were employed for analysis. The results indicate that higher consumption of saturated fat and total daily calories, and a higher body mass index (BMI) are associated with accelerated biological aging. Conversely, higher vitamin D intake and a higher healthy lifestyle index (HLI) are linked to decelerated biological aging. These findings highlight the potential impact of specific lifestyle-related factors on biological aging and can serve as a reference for applying healthy lifestyle improvements in future disease prevention studies.
DNA甲基化已被确认为生物年龄的替代指标，是预测未来发病和死亡结果的潜在工具。本研究旨在探讨生活方式模式与英国男性表观遗传变化之间的关联。在一项涉及221名参与者的前瞻性研究中，使用了五个生物年龄时钟来研究这些表观遗传标记与生活方式相关因素之间的关系。采用斯皮尔曼相关性检验、皮尔逊相关性检验和单变量线性回归进行分析。结果表明，饱和脂肪和每日总热量的摄入量较高，以及体重指数（BMI）较高与生物衰老加速有关。相反，维生素D摄入量较高和健康生活方式指数（HLI）较高与生物衰老减缓有关。这些发现突出了特定生活方式相关因素对生物衰老的潜在影响，并可为未来疾病预防研究中应用健康生活方式改善措施提供参考。
