Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Division of Biostatistics, Washington University, St. Louis, MO 63110, USA.
Aging (Albany NY). 2023 Jan 5;15(2):371-395. doi: 10.18632/aging.204467.
Alcohol is a widely consumed substance in the United States, however its effect on aging remains understudied. In this study of young adults, we examined whether cumulative alcohol consumption, i.e., alcohol years of beer, liquor, wine, and total alcohol, and recent binge drinking, were associated with four measures of age-related epigenetic changes via blood DNA methylation. A random subset of study participants in the Coronary Artery Risk Development in Young Adults Study underwent DNA methylation profiling using the Illumina MethylationEPIC Beadchip. Participants with alcohol consumption and methylation data at examination years 15 ( = 1,030) and 20 ( = 945) were included. Liquor and total alcohol consumption were associated with a 0.31-year ( = 0.002) and a 0.12-year ( = 0.013) greater GrimAge acceleration (GAA) per additional five alcohol years, while beer and wine consumption observed marginal ( = 0.075) and no associations ( = 0.359) with GAA, respectively. Any recent binge drinking and the number of days of binge drinking were associated with a 1.38-year ( < 0.001) and a 0.15-year ( < 0.001) higher GAA, respectively. We observed statistical interactions between cumulative beer ( < 0.001) and total alcohol ( = 0.004) consumption with chronological age, with younger participants exhibiting a higher average in GAA compared to older participants. No associations were observed with the other measures of epigenetic aging. These results suggest cumulative liquor and total alcohol consumption and recent binge drinking may alter age-related epigenetic changes as captured by GAA. With the increasing aging population and widespread consumption of alcohol, these findings may have potential implications for lifestyle modification to promote healthy aging.
在美国，酒精是一种广泛消费的物质，但它对衰老的影响仍研究不足。在这项对年轻人的研究中，我们通过血液 DNA 甲基化检查了累积饮酒量（即啤酒、白酒、葡萄酒和总酒精的饮酒年数）和近期 binge drinking 是否与四种与年龄相关的表观遗传变化有关。冠状动脉风险发展在年轻人研究中的研究参与者的随机亚组接受了 Illumina MethylationEPIC Beadchip 的 DNA 甲基化分析。包括在检查年 15 岁（= 1030）和 20 岁（= 945）有酒精摄入量和甲基化数据的参与者。白酒和总酒精摄入量每增加五饮酒年与 0.31 岁（= 0.002）和 0.12 岁（= 0.013）的 GrimAge 加速（GAA）增加相关，而啤酒和葡萄酒摄入量与 GAA 呈边际相关（= 0.075）和无关联（= 0.359）。任何最近的 binge drinking 和 binge drinking 的天数与 GAA 分别增加 1.38 岁（< 0.001）和 0.15 岁（< 0.001）。我们观察到累积啤酒（< 0.001）和总酒精（= 0.004）摄入量与实际年龄之间的统计学相互作用，年轻参与者的 GAA 平均水平高于年长参与者。与其他表观遗传衰老测量没有关联。这些结果表明，累积的白酒和总酒精摄入量和近期 binge drinking 可能会改变 GAA 所捕捉到的与年龄相关的表观遗传变化。随着老龄化人口的增加和酒精的广泛消费，这些发现可能对促进健康老龄化的生活方式改变具有潜在意义。
