Deep Longevity, Hong Kong.
Department of Biological Sciences, University of Lethbridge, Canada.
Ageing Res Rev. 2023 Jul;88:101956. doi: 10.1016/j.arr.2023.101956. Epub 2023 May 19.
Epigenetic aging clocks have gained significant attention as a tool for predicting age-related health conditions in clinical and research settings. They have enabled geroscientists to study the underlying mechanisms of aging and assess the effectiveness of anti-aging therapies, including diet, exercise and environmental exposures. This review explores the effects of modifiable lifestyle factors' on the global DNA methylation landscape, as seen by aging clocks. We also discuss the underlying mechanisms through which these factors contribute to biological aging and provide comments on what these findings mean for people willing to build an evidence-based pro-longevity lifestyle.
表观遗传衰老时钟作为一种预测临床和研究环境中与年龄相关健康状况的工具，引起了广泛关注。它们使老年科学家能够研究衰老的潜在机制，并评估包括饮食、运动和环境暴露在内的抗衰老疗法的效果。本综述探讨了可改变的生活方式因素对衰老时钟所观察到的全球 DNA 甲基化景观的影响。我们还讨论了这些因素促进生物衰老的潜在机制，并就这些发现对愿意建立基于证据的长寿生活方式的人意味着什么发表了评论。
