Lebbe Ahamed, Aboulwafa Ali, Bayraktar Nuran, Mushannen Beshr, Ayoub Sama, Sarker Shaunak, Abdalla Marwan Nour, Mohammed Ibrahim, Mushannen Malik, Yagan Lina, Zakaria Dalia
Medical Department, Weill Cornell Medicine-Qatar, Doha 24144, Qatar.
Department of Medicine, Albany Medical College, New York, NY 12208, USA.
Biomedicines. 2024 Sep 10;12(9):2065. doi: 10.3390/biomedicines12092065.
The SARS-CoV-2 virus caused a pandemic in the 2020s, which affected almost every aspect of life. As the world is recovering from the effect of the coronavirus, the concept of post-COVID-19 syndrome has emerged. Multiple organ systems have been implicated, including the liver. We aim to identify and analyze the reported cases of severe and long-term parenchymal liver injury post-COVID-19 infection. Several databases were used to conduct a comprehensive literature search to target studies reporting cases of severe and long-term parenchymal liver injury post-COVID-19 infection. Screening, data extraction, and cross checking were performed by two independent reviewers. Only 22 studies met our inclusion criteria. Our results revealed that liver steatosis, non-alcoholic fatty liver disease (NAFLD), and cirrhosis were the most reported liver associated complications post-COVID-19 infection. Moreover, complications like acute liver failure, hepatitis, and liver hemorrhage were also reported. The mechanism of liver injury post-COVID-19 infection is not fully understood. The leading proposed mechanisms include the involvement of the angiotensin-converting enzyme-2 (ACE-2) receptor expressed in the liver and the overall inflammatory state caused by COVID-19 infection. Future studies should incorporate longer follow-up periods, spanning several years, for better insight into the progression and management of such diseases.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒在21世纪20年代引发了一场大流行，几乎影响到生活的方方面面。随着世界从新冠病毒的影响中恢复，新冠后综合征的概念应运而生。多个器官系统都受到了牵连，包括肝脏。我们旨在识别和分析新冠病毒感染后严重和长期实质性肝损伤的报告病例。使用了几个数据库进行全面的文献检索，以查找报告新冠病毒感染后严重和长期实质性肝损伤病例的研究。由两名独立评审员进行筛选、数据提取和交叉核对。只有22项研究符合我们的纳入标准。我们的结果显示，肝脂肪变性、非酒精性脂肪性肝病（NAFLD）和肝硬化是新冠病毒感染后报告最多的肝脏相关并发症。此外，还报告了急性肝衰竭、肝炎和肝出血等并发症。新冠病毒感染后肝损伤的机制尚未完全明确。主要提出的机制包括肝脏中表达的血管紧张素转换酶2（ACE-2）受体的参与以及新冠病毒感染引起的整体炎症状态。未来的研究应纳入数年的更长随访期，以便更好地了解此类疾病的进展和管理。
