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多器官功能衰竭与奥密克戎:一例疑似新冠后胆管病病例

Multiorgan Failure and Omicron: A Suspected Case of Post-COVID-19 Cholangiopathy.

作者信息

Anguiano-Albarran Ricardo, Cain Daniel, Ashfaq Mohammad, Modi Apurva, Gautam Shovendra

机构信息

Internal Medicine, Texas Christian University School of Medicine - Internal Medicine Residency Program, Fort Worth, USA.

Transplant Hepatology, Baylor Simmons Transplant Institute, Baylor Scott & White All Saints Medical Center, Fort Worth, USA.

出版信息

Cureus. 2023 Feb 15;15(2):e35010. doi: 10.7759/cureus.35010. eCollection 2023 Feb.

DOI:10.7759/cureus.35010
PMID:36938182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10021348/
Abstract

Since the declaration of a global pandemic by the World Health Organization on March 11, 2020, coronavirus disease 2019 (COVID-19) has impacted millions worldwide. This complex disease process has been primarily associated with respiratory illness. As we continue to learn about COVID-19, there appears to be a growing spectrum of non-pulmonary manifestations. A major topic of interest is hepatic dysfunction related to COVID-19, specifically the growing number of cases involving acute liver failure in the setting of COVID-19. Here, we present a rare case of a patient with COVID-19 antibodies, negative inpatient COVID-19 testing, jaundice, and elusive multiorgan dysfunction.

摘要

自世界卫生组织于2020年3月11日宣布全球大流行以来,2019冠状病毒病(COVID-19)已影响全球数百万人。这一复杂的疾病过程主要与呼吸系统疾病有关。随着我们对COVID-19的不断了解,非肺部表现的范围似乎在不断扩大。一个主要的研究热点是与COVID-19相关的肝功能障碍,特别是在COVID-19背景下涉及急性肝衰竭的病例数量不断增加。在此,我们报告一例罕见病例,该患者有COVID-19抗体,住院COVID-19检测呈阴性,伴有黄疸和难以捉摸的多器官功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a68/10021348/9552ad7deb8d/cureus-0015-00000035010-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a68/10021348/a7387af356a6/cureus-0015-00000035010-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a68/10021348/9552ad7deb8d/cureus-0015-00000035010-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a68/10021348/a7387af356a6/cureus-0015-00000035010-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a68/10021348/9552ad7deb8d/cureus-0015-00000035010-i02.jpg

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2
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Hepatology. 2022 Dec;76(6):1563-1575. doi: 10.1002/hep.32582. Epub 2022 Jun 18.
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The Association of COVID-19 and Reactive Oxygen Species Modulator 1 (ROMO1) with Oxidative Stress.
新型冠状病毒肺炎(COVID-19)与活性氧调节因子1(ROMO1)和氧化应激的关联
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Antibody titers and breakthrough infections with Omicron SARS-CoV-2.奥密克戎SARS-CoV-2的抗体滴度和突破性感染
J Infect. 2022 Apr;84(4):e13-e15. doi: 10.1016/j.jinf.2022.01.044. Epub 2022 Feb 3.
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The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery.髓过氧化物酶的多种作用:从炎症与免疫到生物标志物、药物代谢及药物研发。
Redox Biol. 2021 Oct;46:102109. doi: 10.1016/j.redox.2021.102109. Epub 2021 Aug 21.
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Doxycycline-induced cholestatic liver injury.强力霉素诱导的胆汁淤积性肝损伤。
Clin J Gastroenterol. 2021 Oct;14(5):1503-1510. doi: 10.1007/s12328-021-01475-7. Epub 2021 Jul 6.
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