Ng Wen-Jie, Wong Fai-Chu, Abd Manan Fazilah, Chow Yit-Lai, Ooi Ai-Lin, Ong Mei-Kying, Zhang Xuewu, Chai Tsun-Thai
Department of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia.
Centre for Biomedical and Nutrition Research, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia.
Foods. 2024 Sep 18;13(18):2945. doi: 10.3390/foods13182945.
Antioxidant peptides derived from aquatic organisms have attracted tremendous research interest due to their potential applications in human health. Tilapia is one of the most widely farmed aquaculture species globally. The current understanding of tilapia-derived antioxidant peptides is gradually expanding. This review discusses the current knowledge of peptides and protein hydrolysates derived from tilapia muscle, skin, and scales, whose antioxidant capacity has been validated in various cellular and in vivo models. To date, at least 16 peptides and several hydrolysates have been identified from tilapia that protect human and non-human cell models against oxidative injury. Tilapia hydrolysates and peptide mixtures have also shown protective effects in animal models of oxidative stress-associated diseases and exercise-induced oxidative injury and fatigue. The key mechanisms of tilapia hydrolysates and peptide mixtures involve enhancing antioxidant enzyme activities and suppressing radical production. Notably, such hydrolysates also exerted additional in vivo functions, such as anti-inflammatory, anti-diabetic, wound healing, and antiaging properties. Taken together, tilapia-derived antioxidant peptides and hydrolysates represent a valuable source of functional ingredients for applications in functional food, dietary supplements, and therapeutic applications. Continued research into their health benefits is warranted in the future.
源自水生生物的抗氧化肽因其在人类健康方面的潜在应用而引起了极大的研究兴趣。罗非鱼是全球养殖最广泛的水产养殖品种之一。目前对罗非鱼源抗氧化肽的认识正在逐渐扩大。本综述讨论了源自罗非鱼肌肉、皮肤和鳞片的肽和蛋白质水解物的现有知识，其抗氧化能力已在各种细胞和体内模型中得到验证。迄今为止，已从罗非鱼中鉴定出至少16种肽和几种水解物，它们可保护人类和非人类细胞模型免受氧化损伤。罗非鱼水解物和肽混合物在氧化应激相关疾病和运动诱导的氧化损伤及疲劳的动物模型中也显示出保护作用。罗非鱼水解物和肽混合物的关键机制包括增强抗氧化酶活性和抑制自由基产生。值得注意的是，此类水解物还具有其他体内功能，如抗炎、抗糖尿病、伤口愈合和抗衰老特性。综上所述，罗非鱼源抗氧化肽和水解物是功能性食品、膳食补充剂和治疗应用中有价值的功能成分来源。未来有必要继续研究它们对健康的益处。
