Mahajan Roopali, Kalita Jayantee, Jha Vishal, Gutti Nagendra B, Pandey Prakash C, Misra Usha K
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India.
J Clin Med. 2024 Sep 23;13(18):5635. doi: 10.3390/jcm13185635.
: There is paucity of studies on the temporal pattern of recovery of facial, bulbar, sensory, motor, and autonomic dysfunction in Guillain-Barré syndrome (GBS), although many studies have reported short- and long-term functional outcomes. We report the temporal pattern of recovery of various neurological functions in GBS, and compare the pattern of recovery between acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). : Forty-two patients with GBS were prospectively included, and their clinical details, including peak disability on a 0-6 scale, were noted. The day of complete recovery in motor, sensory, facial, bulbar, and autonomic functions during 3 months of follow-up was recorded. : Complete recovery of autonomic function occurred in all (median, 12 days), bulbar weakness in 91.3% (median, 15 days), facial weakness in 86.2% (median, 19 days), and sensory functions in 82.1% (median, 20 days). Only 9.5% of patients achieved normal motor function within 3 months. The days of complete recovery of bulbar, facial, autonomic, and motor deficits were comparable between AIDP and AMAN. Demyelinating GBS had an earlier recovery of bulbar and sensory functions. : The neurological recovery in GBS occurs first in the autonomic, followed by the bulbar, facial, sensory, and motor functions. The demyelinating type had an earlier recovery of bulbar and sensory functions.
尽管许多研究报告了吉兰-巴雷综合征(GBS)的短期和长期功能结局,但关于面部、延髓、感觉、运动和自主神经功能障碍恢复的时间模式的研究却很少。我们报告了GBS中各种神经功能恢复的时间模式,并比较了急性炎症性脱髓鞘性多发性神经根神经病(AIDP)和急性运动轴索性神经病(AMAN)之间的恢复模式。前瞻性纳入了42例GBS患者,并记录了他们的临床细节,包括0-6级的最大残疾程度。记录了随访3个月期间运动、感觉、面部、延髓和自主神经功能完全恢复的日期。所有患者的自主神经功能均完全恢复(中位数为12天),91.3%的患者延髓肌无力完全恢复(中位数为15天),86.2%的患者面部肌无力完全恢复(中位数为19天),82.1%的患者感觉功能完全恢复(中位数为20天)。只有9.5%的患者在3个月内达到正常运动功能。AIDP和AMAN之间延髓、面部、自主神经和运动功能缺损完全恢复的天数相当。脱髓鞘性GBS的延髓和感觉功能恢复较早。GBS的神经功能恢复首先发生在自主神经,其次是延髓、面部、感觉和运动功能。脱髓鞘型的延髓和感觉功能恢复较早。