Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan.
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Int J Mol Sci. 2024 Sep 12;25(18):9878. doi: 10.3390/ijms25189878.
This study examined the correlation of titin () polymorphisms with the sensitivity of oral squamous cell cancer (OSCC) and clinical characteristics. Six SNPs, including rs10497520, rs12463674, rs12465459, rs2042996, rs2244492, and rs2303838, were evaluated in 322 control groups and 606 patients with oral cancer. We then investigated whether the SNP genotypes rs10497520 had associations with clinical pathological categories. Our data showed that the TC + CC genotype of rs10497520 was associated with moderate/poor tumor cell differentiation. The carriers of rs10497520 polymorphic variant "TC + CC" in OSCC patients with cigarette smoking were linked with poor tumor differentiation ( = 0.008). Our results suggest that the SNP rs10497520 is a possible genetic marker for oral cancer patients in the cigarette-smoking population. The rs10497520 polymorphisms may be essential biomarkers to predict the onset and prognosis of oral cancer disease.
本研究探讨了肌联蛋白（）多态性与口腔鳞状细胞癌（OSCC）敏感性及临床特征的相关性。在 322 名对照组和 606 名口腔癌患者中，评估了六个 SNP（rs10497520、rs12463674、rs12465459、rs2042996、rs2244492 和 rs2303838）。然后，我们调查了 SNP 基因型 rs10497520 是否与临床病理分类有关。我们的数据显示，rs10497520 的 TC+CC 基因型与中等/差的肿瘤细胞分化有关。在吸烟的 OSCC 患者中，rs10497520 多态性变异“TC+CC”的携带者与肿瘤分化差有关（=0.008）。我们的结果表明，SNP rs10497520 可能是吸烟人群中口腔癌患者的遗传标志物。rs10497520 多态性可能是预测口腔癌发病和预后的重要生物标志物。
