Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Carrera 30 No. 45-03, Bogotá 111311, Colombia.
Universidad Católica de Ávila, Calle Los Canteros s/n, 05005 Ávila, Spain.
Int J Mol Sci. 2024 Sep 17;25(18):10010. doi: 10.3390/ijms251810010.
-tetra(4-methoxyphenyl)calix[4]resorcinarene was synthesized by hydrochloric acid-catalysed cyclocondensation of resorcinol and 4-methoxybenzaldehyde. Under these conditions, the reaction produces a conformational mixture of and structural conformers, which were separated and characterized by chromatographic and spectroscopic techniques. The antioxidant activity of both conformers was measured by using the DPPH assay, through which it was observed that the conformer showed greater antioxidant activity (IC = 47.46 ppm) than the conformer (IC = 78.46 ppm). Additionally, it was observed that the mixture of both conformers presented lower antioxidant activity than either conformer in isolation. The results found suggest that the conformer has efficient antioxidant activity that makes it a potential target for further research.
四（4-甲氧基苯基）杯[4]芳烃是由间苯二酚和 4-甲氧基苯甲醛在盐酸催化下缩合而成的。在这些条件下，反应生成和结构构象的构象混合物，通过色谱和光谱技术对其进行分离和表征。通过 DPPH 法测定了两种构象的抗氧化活性，结果表明，构象的抗氧化活性（IC = 47.46ppm）大于构象（IC = 78.46ppm）。此外，还观察到两种构象的混合物的抗氧化活性低于两者各自单独存在时的活性。研究结果表明，构象具有有效的抗氧化活性，使其成为进一步研究的潜在目标。
