Lee Jung-Seop, Song In-Ho, Shinde Pramod B, Nimse Satish Balasaheb
Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 200702, Korea.
Natural Products & Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Academy of Scientific and Innovative Research (AcSIR), Council of Scientific and Industrial Research (CSIR), Bhavnagar 364002, Gujarat, India.
Antioxidants (Basel). 2020 Sep 14;9(9):859. doi: 10.3390/antiox9090859.
Oxidative stress due to the high levels of reactive oxygen species (ROS) that damage biomolecules (lipids, proteins, DNA) results in acute inflammation. However, without proper intervention, acute inflammation progresses to chronic inflammation and then to several chronic diseases, including cancer, myocardial infarction, cardiovascular diseases, chronic inflammation, atherosclerosis, and more. There has been extensive research on the antioxidants of natural origin. However, there are myriad possibilities for the development of synthetic antioxidants for pharmacological applications. There is an increasing interest in the identification of novel synthetic antioxidants for the modulation of biochemical processes related to ROS. In this regard, derivatives of supramolecules, such as calix[n]arene, resorcinarene, calixtyrosol, calixpyrrole, cucurbit[n]uril, porphyrin etc. are gaining attention for their abilities to scavenge the free radicals. Supramolecular chemistry offers excellent scaffolds for the development of novel antioxidants that can be used to modulate free radical reactions and to improve the disorders related to oxidative stress. This review focuses on the interdisciplinary approach for the design and development of novel synthetic antioxidants based on supramolecular scaffolds, with potentially protective effects against oxidative stress.
由高水平的活性氧（ROS）引起的氧化应激会损害生物分子（脂质、蛋白质、DNA），从而导致急性炎症。然而，如果没有适当的干预，急性炎症会发展为慢性炎症，进而引发多种慢性疾病，包括癌症、心肌梗死、心血管疾病、慢性炎症、动脉粥样硬化等等。人们对天然来源的抗氧化剂进行了广泛研究。然而，开发用于药理学应用的合成抗氧化剂仍有无数可能性。人们越来越关注鉴定新型合成抗氧化剂，以调节与ROS相关的生化过程。在这方面，超分子衍生物，如杯[n]芳烃、间苯二酚芳烃、杯酚、杯吡咯、葫芦[n]脲、卟啉等，因其清除自由基的能力而受到关注。超分子化学为开发新型抗氧化剂提供了优良的支架，这些抗氧化剂可用于调节自由基反应并改善与氧化应激相关的病症。本综述重点关注基于超分子支架设计和开发新型合成抗氧化剂的跨学科方法，这些抗氧化剂可能对氧化应激具有保护作用。
