Olar Loredana Elena, Tomoiagă Vasile Daniel, Mârza Sorin Marian, Papuc Ionel, Beteg Ioan Florin, Peștean Petru Cosmin, Musteață Mihai, Lăcătuș Caroline Maria, Marica Raluca, Pașca Paula Maria, Purdoiu Robert Cristian, Lăcătuș Radu
Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Life Sciences Institute, 3-5 Manastur Avenue, 400372 Cluj-Napoca, Romania.
Life (Basel). 2024 Sep 5;14(9):1121. doi: 10.3390/life14091121.
Coenurosis is a parasitic disease caused by the larval stage of , , typically found in the central nervous system of different livestock such as sheep and goats. The blood plasma from fifteen clinically healthy sheep and six sheep with neurological symptoms was studied by fluorescence spectroscopy in order to establish the contribution of kynurenic acid (KYNA), the neuroprotective metabolite of the kynurenine pathway, to the total fluorescence of the plasma. CT scans were used to confirm the presence of cysts in the central nervous system of sheep with neurological symptoms. The fluorescence spectroscopy analysis and further spectra deconvolution process revealed some significantly lower KYNA contributions to the total plasma fluorescence in sheep with coenurosis compared to healthy controls. Our results indicate that KYNA emission parameters could serve as valuable diagnostic markers, particularly for detecting preclinical cases of coenurosis, thus allowing for improved farm management practices.
多头蚴病是一种由 、 幼虫阶段引起的寄生虫病，通常出现在绵羊和山羊等不同家畜的中枢神经系统中。对15只临床健康绵羊和6只出现神经症状绵羊的血浆进行了荧光光谱研究，以确定犬尿氨酸途径的神经保护性代谢产物犬尿喹啉酸（KYNA）对血浆总荧光的贡献。CT扫描用于确认出现神经症状绵羊中枢神经系统中囊肿的存在。荧光光谱分析及进一步的光谱去卷积过程显示，与健康对照相比，多头蚴病绵羊血浆中KYNA对总血浆荧光的贡献显著降低。我们的结果表明，KYNA发射参数可作为有价值的诊断标志物，特别是用于检测多头蚴病的临床前病例，从而改善农场管理实践。
