Rizzetto Giulio, De Simoni Edoardo, Gioacchini Helena, Molinelli Elisa, Offidani Annamaria, Simonetti Oriana
Clinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, Italy.
Life (Basel). 2024 Sep 7;14(9):1128. doi: 10.3390/life14091128.
Alopecia areata (AA) is a non-scarring autoimmune disease requiring long-term treatments. Topical, intralesional or systemic corticosteroids are the first option. However, considering the risk of skin atrophy and the possible lack of clinical response, new treatment options are urgently needed. A fractional carbon dioxide laser (FCL) has been proven to be effective alone or in combination with other drugs. However, no study has ever evaluated the association between FCL and topical tacrolimus. We report three cases of AA resistant to corticosteroids for at least 12 months, treated with topical tacrolimus 0.1% ointment and FCL on some patches. After 16 weeks from the beginning of treatment, all patients showed improvement in clinical and trichoscopic parameters in the areas treated in combination. FCL and tacrolimus may represent a new therapeutic option, but further studies are needed for confirmation.
斑秃（AA）是一种非瘢痕性自身免疫性疾病，需要长期治疗。外用、皮损内注射或全身使用皮质类固醇是首选治疗方法。然而，考虑到皮肤萎缩的风险以及可能缺乏临床反应，迫切需要新的治疗选择。分次二氧化碳激光（FCL）已被证明单独使用或与其他药物联合使用有效。然而，尚无研究评估FCL与外用他克莫司之间的关联。我们报告了3例对皮质类固醇耐药至少12个月的斑秃患者，对部分皮损使用0.1%外用他克莫司软膏和FCL进行治疗。治疗开始16周后，所有患者联合治疗区域的临床和毛囊镜检查参数均有改善。FCL和他克莫司可能代表一种新的治疗选择，但需要进一步研究加以证实。
