Salah Manal, Samy Nevien, Fawzy Marwa Mohamed, Farrag Abdel Razik, Shehata Hany, Hany Aya
Department of Medical Applications of Laser, National Institute of Laser Enhanced Sciences (N.I.L.E.S), Cairo University, Cairo, Egypt.
Department of Dermatology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
J Lasers Med Sci. 2020 Winter;11(1):29-36. doi: 10.15171/jlms.2020.06. Epub 2019 Jan 18.
Recently, laser treatment for hair loss has become very popular. Laser-assisted drug delivery (LAD) is an evolving technology with potentially broad clinical applications. This work aims at inspecting the effect of the fractional carbon dioxide laser (CO ) on improving the delivery of minoxidil in patients with androgenetic alopecia and detecting the role of the fractional CO laser in its treatment. We enrolled 45 Egyptians with male androgenetic alopecia (MAGA); clinical grading was assessed based on Norwood-Hamilton classification. The patients were divided into 3 groups: the first group (combined group) received the fractional CO laser session followed by topical application of minoxidil and also in between sessions; the second group received fractional CO laser sessions only and 6 sessions with 2-week intervals were performed; the third group applied topical minoxidil only for 3 months. Global photographs and dermoscopic assessments were performed before treatment and 3 months after the treatment. Several dermoscopic findings were detected, including peripilar sign, hair diversity, yellow spot, white dots, and arborizing red lines. The number of double hair units significantly increased after the treatment in the combined group. The mean number of hair after the treatment in the 3 groups significantly increased, mostly in the combined group. The hair thickness (thin & thick) significantly increased after the treatment in the combined group and the fractional group; however, in the minoxidil group, only thin hair thickness increased. In all the 3 groups, there was a significant improvement in hair count and thickness. The ablative fractional CO laser alone or combined with minoxidil may serve as an additional treatment for MAGA.
最近，激光治疗脱发变得非常流行。激光辅助药物递送（LAD）是一项不断发展的技术，具有潜在的广泛临床应用。这项工作旨在研究分次二氧化碳激光（CO₂）对改善雄激素性脱发患者米诺地尔递送的效果，并检测分次CO₂激光在其治疗中的作用。我们招募了45名患有男性雄激素性脱发（MAGA）的埃及人；根据诺伍德 - 汉密尔顿分类法评估临床分级。患者被分为3组：第一组（联合组）接受分次CO₂激光治疗，随后局部应用米诺地尔，且在治疗期间也应用；第二组仅接受分次CO₂激光治疗，共进行6次治疗，间隔2周；第三组仅局部应用米诺地尔3个月。在治疗前和治疗后3个月进行整体照片和皮肤镜评估。检测到了几种皮肤镜表现，包括毛周征、毛发多样性、黄斑、白点和树枝状红线。联合组治疗后双毛单位数量显著增加。3组治疗后的平均毛发数量均显著增加，主要是联合组。联合组和分次激光组治疗后毛发粗细（细发和粗发）均显著增加；然而，在米诺地尔组，仅细发粗细增加。在所有3组中，毛发数量和粗细均有显著改善。剥脱性分次CO₂激光单独或与米诺地尔联合使用可作为MAGA的一种额外治疗方法。
