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1型糖尿病患者饮食习惯与血糖控制之间的相互作用:一项全面的前瞻性连续血糖监测研究

The Interplay between Dietary Habits and Glycemic Control in Type 1 Diabetes: A Comprehensive Prospective FGM Study.

作者信息

Gradinjan Centner Maja, Čačić Kenjerić Daniela, Schönberger Ema, Centner Hrvoje, Sladić Rimac Daria, Steiner Kristina, Marušić Romana, Bakula Miro, Fabris Vitković Daniela, Mihaljević Ivica, Ćurčić Ines Bilić, Canecki Varžić Silvija

机构信息

Department of Endocrinology, Clinical Hospital Center Osijek, 31000 Osijek, Croatia.

Faculty of Food Technology Osijek, University J. J. Strossmayer, 31000 Osijek, Croatia.

出版信息

Life (Basel). 2024 Sep 12;14(9):1153. doi: 10.3390/life14091153.

Abstract

Type 1 diabetes has become prevalent among the adult population, who have increasingly gained access to sensing technology. This study delved into the impact of diet, nutritional status, and the use of a continuous glucose monitoring system (CGM) on glycemic regulation among adults diagnosed with T1D. Employing a prospective design, data were gathered from 151 participants aged 18-60 across multiple cycles. Participants utilized the FreeStyle Libre (FSL) Flash Glucose Monitoring (FGM) System and provided dietary details via questionnaires and diaries. The findings unveiled correlations between dietary patterns and glycemic control, with higher protein intake associated with improved glycated hemoglobin A1C values ( = 0.019), yet elevated fat and protein consumption was linked to heightened rates of hyperglycemia. Conversely, no significant relationship was observed between dietary variables and hypoglycemia occurrence. Interestingly, subjects with more readings of glucose levels consumed fewer carbohydrates ( = 0.004) and more proteins ( = 0.000). Furthermore, physical activity and marital status correlated with glycemic stability, while higher education was associated with enhanced glycemic control ( = 0.021). This study confirmed the importance of structured education on glycemic regulation and the importance of dietary patterns in glucose management. Also, the educational role of the FGM system in changing dietary habits was confirmed, which is one of the key factors for improving glycemic regulation in continuous glucose monitoring system users.

摘要

1型糖尿病在成年人中变得越来越普遍,他们越来越容易接触到传感技术。本研究深入探讨了饮食、营养状况以及使用连续血糖监测系统(CGM)对被诊断为1型糖尿病的成年人血糖调节的影响。采用前瞻性设计,在多个周期内从151名年龄在18至60岁的参与者中收集数据。参与者使用了FreeStyle Libre(FSL)闪光葡萄糖监测(FGM)系统,并通过问卷和日记提供饮食细节。研究结果揭示了饮食模式与血糖控制之间的相关性,较高的蛋白质摄入量与糖化血红蛋白A1C值的改善相关( = 0.019),然而脂肪和蛋白质摄入量的增加与高血糖发生率的升高有关。相反,未观察到饮食变量与低血糖发生之间存在显著关系。有趣的是,血糖水平读数较多的受试者碳水化合物摄入量较少( = 0.004),蛋白质摄入量较多( = 0.000)。此外,身体活动和婚姻状况与血糖稳定性相关,而较高的教育程度与更好的血糖控制相关( = 0.021)。本研究证实了结构化教育对血糖调节的重要性以及饮食模式在血糖管理中的重要性。此外,还证实了FGM系统在改变饮食习惯方面的教育作用,这是改善连续血糖监测系统使用者血糖调节的关键因素之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fe/11432966/226d5cdc7480/life-14-01153-g001.jpg

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