Undergraduate Course in Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte 30535-500, Brazil.
Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil.
Int J Environ Res Public Health. 2024 Sep 18;21(9):1227. doi: 10.3390/ijerph21091227.
The present study aimed to compare the prevalence of oral problems between individuals with rare genetic diseases that affect skeletal development and individuals without rare diseases. A cross-sectional study was conducted with 210 individuals between two and fifty-four years of age: 105 with rare genetic diseases (27 with mucopolysaccharidosis [MPS] and 78 with osteogenesis imperfecta [OI]) and 105 without rare diseases. The rare genetic disease group was recruited from hospital units that provide care for patients with MPS and OI in five states of Brazil, and the other group was recruited from the same location. The participants were examined with regards to malocclusion, dental anomalies, dental caries, and gingivitis. A questionnaire was administered addressing individual, sociodemographic, and behavioral characteristics as well as dental history. A descriptive analysis was performed, followed by unadjusted and adjusted binary logistic regression analyses. The mean age was 14.1 ± 12.2 years. Individuals with a rare disease were 12.9-fold more likely to have some type of oral problem (95% CI: 3.7-44.7) compared to the group without rare diseases. The prevalence of oral problems was higher among Brazilians with MPS and OI compared to normotypical individuals.
本研究旨在比较患有影响骨骼发育的罕见遗传疾病的个体和没有罕见疾病的个体之间口腔问题的患病率。采用横断面研究方法，对 210 名年龄在 2 至 54 岁之间的个体进行了研究：105 名患有罕见遗传疾病（27 名患有黏多糖贮积症[MPS]，78 名患有成骨不全症[OI]）和 105 名没有罕见疾病的个体。罕见遗传疾病组是从巴西五个州为 MPS 和 OI 患者提供护理的医院单位招募的，而另一组则从同一地点招募。研究对象接受了错颌畸形、牙齿异常、龋齿和牙龈炎检查。采用问卷对个体、社会人口统计学和行为特征以及牙科史进行了评估。进行了描述性分析，随后进行了未调整和调整后的二元逻辑回归分析。平均年龄为 14.1 ± 12.2 岁。与无罕见疾病组相比，患有罕见疾病的个体发生某种口腔问题的可能性高 12.9 倍（95%CI：3.7-44.7）。与正常体型个体相比，患有 MPS 和 OI 的巴西人患口腔问题的患病率更高。
